Different Strategies to Reduce Contrast Medium in Computed Tomography Pulmonary Angiography Using Spectral Detector CT
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 330
- 试验地点
- 2
- 主要终点
- Contrast enhancement (Vascular attenuation)
研究概览
简要总结
The purpose of this study is to assess the effect of three different strategies to inject at reduced volume of contrast medium in Computed Tomography Pulmonary Angiography (CTPA).
330 patients referred for CTPA are randomized to receive either a low-concentration, a low-volume or a saline-diluted injection.
Effects on the level and homogeneity of contrast enhancement are measured and compared between groups.
详细描述
Spectral detector CT facilitates large reductions in contrast medium in vascular CT examinations. To our knowledge, no studies have so far compared different strategies to inject this reduced contrast dose.
The purpose of this study is to assess the effect of three different strategies to inject at reduced volume of contrast medium in Computed Tomography Pulmonary Angiography (CTPA).
330 patients referred for clinically indicated CTPA are randomized to receive either a low-concentration, a low-volume or a saline-diluted injection. All patients receive the same amount of iodine (140 mg/kg).
Effects on the level and homogeneity of contrast enhancement, image noise, contrast-to-noise-ratio and signal-to-noise-ratio are measured in the CT images and the results are compared between groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Acquired CT images are identical for all participants. The study arm is unknown to all, except the radiographers (radiology technicians) performing the examination.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inpatients and outpatients with kidney function (eGFR) allowing for safe administration of contrast dose (as calculated with the OmniVis calculator).
- •Patients with clinical suspicion of disease of PE
- •Referral to CTPA diagnosis, treatment planning or follow-up.
- •Peripheral venous catheter (PVC) =/< 18 G
排除标准
- •Contraindication to iodinated contrast medium
- •Age < 18 years
- •Lack of informed consent
- •Pregnancy
结局指标
主要结局
Contrast enhancement (Vascular attenuation)
时间窗: Measured on the CT images from the examination performed at enrollment
Contrast enhancement measured as attenuation in the pulmonary artery Branches on the acquired CTPA examination
次要结局
- Contrast to noise ratio (CNR)(Measured on the CT images from the examination performed at enrollment)
- Homogeneity of contrast enhancement (image noise)(Measured on the CT images from the examination performed at enrollment)
- Signal to noise ratio (SNR)(Measured on the CT images from the examination performed at enrollment)
研究者
Peter Maehre Lauritzen
Principal Investigator
University Hospital, Akershus