Combined Role of PET and MEG in Nonlesional Epilepsy in Pediatric Population
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Epilepsy
- Sponsor
- The Hospital for Sick Children
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- The concordance rate of FDG-PET and MEG with video EEG
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The first aim of this study are to evaluate the lobar concordance of FDG-PET and MEG with intracranial electrographic study in children with intractable partial epilepsy. The second aim is to determine if the combined role of FDG-PET and MEG improve detection of epileptogenic zone as defined by invasive intracranial recordings.
Detailed Description
Children with poorly controlled epilepsy are extensively investigated with various tools including MR brain, electroencephalography (EEG), magnetoencephalography (MEG) or position emission tomography (PET) scans. When MR brain does not show an abnormality, the patient is said to have nonlesional epilepsy. In these cases, it is even more crucial to be able to identify the epileptogenic zone, depending on availability of investigative tool. Recognizing that individual modalities have limitations, the aim of this study is to determine if combining non-invasive investigations with MEG and PET, which respectively evaluate the electrical and metabolic activity of the brain, could improve the children with intractable nonlesional epilepsy with MEG and PET and compared this with invasive intracranial monitoring. The endpoint of the study being agreement on localizations of epileptogenic zone using PET and MEG individually and in combination and comparing this with invasive intracranial monitoring.
Investigators
Amer Shammas
Nuclear Medicine Radiologist
The Hospital for Sick Children
Eligibility Criteria
Inclusion Criteria
- •Children between the ages 0-18 years with (1) nonlesional intractable focal epilepsy and (2) those with discordant clinical and EEG findings, who are potential surgical candidates
Exclusion Criteria
- •Patients who are pregnant
Outcomes
Primary Outcomes
The concordance rate of FDG-PET and MEG with video EEG
Time Frame: 3 years
Secondary Outcomes
- The positive and negative predictive values of each modality and combined modalities in assessing the epileptogenic zone.(3 years)