Aspirin Thromboprophylaxis After First-line Total Hip and Knee Replacement

• Conditions: Hip and Knee Prosthesis Implantation

• Registration Number: NCT05128214
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Annually, more than 100,000 total hip prostheses (THA) and more than 100,000 total knee prostheses (TKA) are implanted for osteoarthritis in France, and these figures are set to increase significantly in the future as in all industrialized countries. . Venous thrombosis is a potentially serious complication after PTH and PTG, justifying various prophylactic measures. In France, aggressive prophylaxis with low molecular weight heparin (LMWH) or direct oral anticoagulants (DOA) was until recently recommended, because this drug is considered to be the most effective, at the cost of a bleeding risk implicitly assumed but often poorly. evaluated. A recent publication suggests that the risk of bleeding is currently greater than the risk of a thromboembolic event.

More recently, foreign or international recommendations have broadened the range of these recommendations, notably by introducing aspirin as a possible prophylactic agent. While this molecule is potentially less effective than LMWHs or ADOs, it could decrease the risk of iatrogenic hemorrhage. The introduction of enhanced recovery procedures after surgery (RAAC) could decrease the risk of thrombosis without modifying the risk of bleeding, and thereby improve the cost-benefit ratio of aspirin, justifying its recent inclusion in the current French recommendations when The operated follows such a protocol.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-18
• Status Verified: 2021-10
• Study First Submitted: 2021-10-14
• Study First Submitted QC: 2021-11-17
• Study First Posted: 2021-11-19
• Last Update Submitted: 2021-11-23
• Last Update Posted: 2021-11-30
• Primary Completion: 2021-12
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Study of the postoperative thromboembolic complications after implantation of hip and knee prostheses	Files analysed retrospectively from July 01, 2016 to December 31, 2020 will be examined]

Trial Locations

Locations (1)

Service de Chirurgie Orthopédique Pédiatrique - Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France