Evaluation of effectiveness of biomarkers for early diagnosis of acute rejection in renal transplant recipients

Not Applicable

Completed

• Conditions: Diseases of the genitourinary system

• Registration Number: KCT0005991
• Lead Sponsor: Kyungpook National University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-10-31
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1) Newly kidney transplant recipient
2) Aged from 18 to 75
3) High risk of acute rejection (one or more of the following is satisfied)
• HLA mismatch =5
• Pretransplant panel reactive antibody =30%
• Pretransplant desensitization
• Positive for direct cross match
• Extended criteria deceased donor kidney transplantation
4) Induction immunosuppression using anti-thymocyte globulin or basiliximab,and maintenance immunosuppression by tacrolimus, mycophenolic acid and steroid

Exclusion Criteria

1) Active infection
2) HIV, HCV infection
3) Comorbid untreatable ischemic heart disease
4) Abnormality of hematologic exam (hemoglobin <7.0g/dL, leukocyte count <2,500/mm3, absolute neutrophil count <1,500/mm3, platelet count <75,000/mm3)
5) Pregnant
6) Multiorgan trasnplant
7) History of malignancy

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glomerular filtration rate

Secondary Outcome Measures

Name	Time	Method
Occurrence of acute rejection;Rate of graft failure;Rate of kidney biopsy