NCT07659886Not yet recruitingPhase 3
Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures
Interventions
Trial Snapshot
- Phase
- Phase 3
- Status
- Not yet recruiting
- Sponsor
- Atlantic Health System
- Enrollment
- 100
- Locations
- 1
Study Overview
Brief Summary
To evaluate the feasibility, safety, and potential efficacy of applying vancomycin powder locally to open fractures in the emergency department prior to definitive surgical intervention.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Participants aged 18 years or older presenting to the Emergency Department with Gustilo-Anderson Type I, II, or III open fractures.
Exclusion Criteria
- •Known allergy to vancomycin
- •Ballistic open fractures
- •Pregnancy
- •Currently breastfeeding
- •Age younger than 18 years.
Arms & Interventions
Emergency Department Vancomycin Powder
Experimental
Patients receive 1 gram topical vancomycin powder applied to the open fracture wound in the Emergency Department in addition to standard open fracture management.
Intervention: Vancomycin (VAN) treatment (Drug)
Standard Open Fracture Care
Active Comparator
Patients receive standard open fracture management without Emergency Department (ED) vancomycin powder.
Intervention: Standard Open Fracture Care (Other)
Investigators
Kristen De Wilde
Resident physician
Atlantic Health System
Study Sites (1)
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