Comparison of Sevoflurane and Isoflurane on post operative cognitive dysfunction following laparoscopic cholecystectomy.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To find out how Sevoflurane differs from Isoflurane on affecting postoperative cognitive dysfunction following a laparoscopic cholecystectomy surgery.
研究概览
简要总结
Laparoscopic cholecystectomy has been traditionally performed under general anesthesia.
Sevoflurane is a halogenated inhalational agent containing fluorine.It is an excellent choice for smooth and rapid inhalational induction in pediatric and adult patients.The minimum alveolar concentration of Sevoflurane is 2.0%.
Isoflurane is a non-flammable volatile anaesthetic with a pungent etheral odor.The minimum alveolar concentration of Isoflurane is 1.2%.
Postoperative cognitive dysfunction is defined as a new cognitive impairment arising after a surgical or anaesthetic procedure.Its diagnosis requires both pre and postoperative psychometric testing.
The Montreal Cognitive Assessment was designed as a rapid screening instrument for mild cognitive dysfunction.It assesses different cognitive domains attention and concentration , executive functions , memory, language visuoconstructional skills , conceptual thinking, calculations and orientation. The total possible score is 30 points. A score of 26 or above is considered normal.The Montreal Cognitive Assessment has a sensitivity of more than 90 percent for detecting even mild cognitive dysfunction.
In our study we aim to compare the effect of Sevoflurane and Isoflurane on post-operative cognitive dysfunction following laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Those willing to give written.
- •informed consent. 2.ASA physical status I and II patients.
排除标准
- •Refusal of the patient.
- •Age less than 18 years and more than 60 years.
- •Patients above ASA III grade.
- •4.Patients who do not speak hindi or english.
- •Patients who do not have an elementary school education.
结局指标
主要结局
To find out how Sevoflurane differs from Isoflurane on affecting postoperative cognitive dysfunction following a laparoscopic cholecystectomy surgery.
时间窗: until 24 hours post-extubation after the procedure.
次要结局
- 1.To compare the incidence and severity of post operative shivering between sevoflurane and isoflurane.(2.To find out the incidence of post operative nausea and vomiting between sevoflurane and isoflurane.)