Determinants of Muscle Strength in Chronic Kidney Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Disease
- Sponsor
- University Hospital, Montpellier
- Enrollment
- 110
- Locations
- 2
- Primary Endpoint
- Voluntary muscle strength evaluated by handheld dynamometer
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Aim of this study is to determine in chronic kidney disease patients:
- the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment
- the relationship between voluntary muscle strength and muscle mass
- the relationship between voluntary muscle strength and lean body mass
- the correlation between voluntary muscle strength and physical activity
Detailed Description
Aim of this study is to determine in chronic kidney disease patients: * the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer) * the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index) * the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis) * the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)
Investigators
Eligibility Criteria
Inclusion Criteria
- •chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
- •stable clinical condition (absence of infection, stroke or acute decompensation)
Exclusion Criteria
- •chronic kidney disease without extrarenal replacement therapy
- •history of renal transplantation
Outcomes
Primary Outcomes
Voluntary muscle strength evaluated by handheld dynamometer
Time Frame: 1 day
data will be measured in Newton.meter
Secondary Outcomes
- Lean body mass evaluated by electrical bioimpedance analysis(1 day)
- Physical activity estimated using the "Voorrips" score questionnaire(1 day)
- C reactive protein level(1 day)
- Albumin level(1 day)
- Muscle mass estimated by creatinine index evaluation(1 day)