Determinants of Muscle Strength in Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT02806089
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Aim of this study is to determine in chronic kidney disease patients:

* the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment

* the relationship between voluntary muscle strength and muscle mass

* the relationship between voluntary muscle strength and lean body mass

* the correlation between voluntary muscle strength and physical activity

Detailed Description

Aim of this study is to determine in chronic kidney disease patients:

* the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer)

* the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index)

* the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis)

* the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)

Study Timeline

• Study Start: 2016-01-04
• Study First Submitted: 2016-06-06
• Study First Submitted QC: 2016-06-15
• Study First Posted: 2016-06-20
• Status Verified: 2017-01
• Primary Completion: 2017-06-14
• Study Completion: 2017-10
• Last Update Submitted: 2019-02-26
• Last Update Posted: 2019-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
• stable clinical condition (absence of infection, stroke or acute decompensation)

Exclusion Criteria

• chronic kidney disease without extrarenal replacement therapy
• history of renal transplantation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Voluntary muscle strength evaluated by handheld dynamometer	1 day	data will be measured in Newton.meter

Secondary Outcome Measures

Name	Time	Method
Lean body mass evaluated by electrical bioimpedance analysis	1 day	data will be expressed in kilogram
Physical activity estimated using the "Voorrips" score questionnaire	1 day	the score represents the daily physical activity according to a validated scale
C reactive protein level	1 day	the parameter will be measured in milligram/liter
Albumin level	1 day	the parameter will be measured in gram/liter
Muscle mass estimated by creatinine index evaluation	1 day	data will be obtained from plasma creatinine level and will be expressed in milligram/kilogram/day)

Trial Locations

Locations (2)

AIDER; 🇫🇷 Nîmes, France

GCS Help Lapeyronie, CHU Montpellier; 🇫🇷 Montpellier, France