Preventive Effect of Stellate Ganglion Block on Cerebral Vasospasm in Patients Undergoing Aneurysm Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Stellate Ganglion Block
- Conditions
- Intracranial Aneurysm
- Sponsor
- General Hospital of Ningxia Medical University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- The incidence of cerebral vasospasm
- Last Updated
- 9 years ago
Overview
Brief Summary
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
Detailed Description
The vasospasm after cranial aneurysm surgery have a higher incidence, but not have an ideal treatment method. At present, the medical treatment is very limited effect to prevent the perioperative cerebral ischemia.Stellate ganglion block （SGB）is an effective and well-tolerated approach to the treatment of CVS in various clinical settings.Resent study indicated that SGB has a protective effect on delayed cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage.Therefore,we hypothesized that the preoperative SGB would be a effective treatment for improvement of vasospasm after cranial aneurysm surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •aneurysm subarachnoid hemorrhage patients scheduled for cranial aneurysm surgery，
- •ASA grade：Ⅱ-Ⅲ，
- •Hunt～Hess grade :Ⅰ-Ⅲ,
- •have a informed consent.
Exclusion Criteria
- •history of mental illness，
- •local infection who can't do stellate ganglion block，
- •pregnant or lactating，
- •nausea cancer or diabetes，
- •participated the study or other related research in the last 30 days，
- •unruptured aneurysms patients
Arms & Interventions
Intervention 'Stellate Ganglion Block'
Experimental patients will receive a stellate ganglion block with 0.25% ropivacaine 6-8mL on the right side at the level of the sixth cervical vertebrae (C6) before surgery.Then the catheter will be attached to a single use patient-controlled analgesia pump containing 0.2% ropivacaine 150 mL, which will be infused at 2 mL/h.
Intervention: Stellate Ganglion Block
Outcomes
Primary Outcomes
The incidence of cerebral vasospasm
Time Frame: Change from baseline at 2hour,6hour,1day,3day,and 7day after aneurysm surgery
The occurrence of cerebral vasospasm will be diagnosed by using of the transcranial doppler instrument.
Secondary Outcomes
- Perioperative cerebral oxygen metabolism(Change from baseline at 2hour,6hour,1day,3day,and 7day postoperatively)
- The difference of plasma endothelin, melatonin, and S100-β protein level between two groups at each time point(Change from baseline at 2hour,6hour,1day,3day,and 7day postoperatively)
- Postoperative cognitive function(Change from baseline at 2hour,6hour,1day,3day,and 7day after aneurysm surgery)