Preventive Effect of Stellate Ganglion Block on Cerebral Vasospasm in Patients Undergoing Aneurysm Surgery
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The incidence of cerebral vasospasm
研究概览
简要总结
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
详细描述
The vasospasm after cranial aneurysm surgery have a higher incidence, but not have an ideal treatment method. At present, the medical treatment is very limited effect to prevent the perioperative cerebral ischemia.Stellate ganglion block （SGB）is an effective and well-tolerated approach to the treatment of CVS in various clinical settings.Resent study indicated that SGB has a protective effect on delayed cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage.Therefore,we hypothesized that the preoperative SGB would be a effective treatment for improvement of vasospasm after cranial aneurysm surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aneurysm subarachnoid hemorrhage patients scheduled for cranial aneurysm surgery，
- •ASA grade：Ⅱ-Ⅲ，
- •Hunt～Hess grade :Ⅰ-Ⅲ,
- •have a informed consent.
排除标准
- •history of mental illness，
- •local infection who can't do stellate ganglion block，
- •pregnant or lactating，
- •nausea cancer or diabetes，
- •participated the study or other related research in the last 30 days，
- •unruptured aneurysms patients
研究组 & 干预措施
Intervention 'Stellate Ganglion Block'
Experimental patients will receive a stellate ganglion block with 0.25% ropivacaine 6-8mL on the right side at the level of the sixth cervical vertebrae (C6) before surgery.Then the catheter will be attached to a single use patient-controlled analgesia pump containing 0.2% ropivacaine 150 mL, which will be infused at 2 mL/h.
干预措施: Stellate Ganglion Block (Drug)
结局指标
主要结局
The incidence of cerebral vasospasm
时间窗: Change from baseline at 2hour,6hour,1day,3day,and 7day after aneurysm surgery
The occurrence of cerebral vasospasm will be diagnosed by using of the transcranial doppler instrument.
次要结局
- Perioperative cerebral oxygen metabolism(Change from baseline at 2hour,6hour,1day,3day,and 7day postoperatively)
- The difference of plasma endothelin, melatonin, and S100-β protein level between two groups at each time point(Change from baseline at 2hour,6hour,1day,3day,and 7day postoperatively)
- Postoperative cognitive function(Change from baseline at 2hour,6hour,1day,3day,and 7day after aneurysm surgery)