ACTRN12621000006842
Recruiting
未知
A Comparison of Gut Microbiome Profiles in Relation to Cognition and Neuroplasticity across Ageing and Parkinson’s disease
Helen Macpherson0 sites144 target enrollmentJanuary 8, 2021
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Parkinson's disease
- Sponsor
- Helen Macpherson
- Enrollment
- 144
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •50\-80 years for both groups (Healthy older and PD groups) and between 18\-35 years for the healthy younger adult group
- •Presence of PD, as determined through independent neurologist, for PD group. Level of severity (UPDRS stage II and III) will be determined and mild\-moderate PD patients will be included. Note: No early onset PD cases to be included in the study, PD diagnosis has to have occurred at 50 years of age or later.
- •For healthy older group, no neurological conditions present and no first\-degree relatives with PD (determined through self\-report questionnaires). No signs of Parkinsonism or symptoms associated with premotor PD (Assessed through the Unified Parkinson’s Disease Rating Scale (UPDRS stages II and III)
- •greater than or equal to 24/30 for the healthy older group on the Montreal Cognitive Assessment (MoCA), greater than or equal to 21 for the PD group on the MoCA
- •For the healthy younger adult group:
- •Aged between 18\-35 years
- •No neurological/neurodegenerative conditions and no first\-degree relatives with PD (determined through self\-report questionnaires)
- •No signs of Parkinsonism or symptoms associated with premotor PD (Assessed through the Unified Parkinson’s Disease Rating Scale (UPDRS stages II and III)
- •greater than or equal to 24/30 on the MoCA
Exclusion Criteria
- •Taken prebiotics (fibre supplementation, inulin etc.) or probiotics (Over the counter probiotics, , including Yakult or similar products) within previous 3 months
- •Gastrointestinal diseases such as Colitis or Crohn’s disease
- •Obesity (BMI greater or equal to 30\)
- •Drugs/Medication including proton\-pump inhibitors and antibiotic use (within the previous 3 months)
- •Current drug or alcohol abuse
- •Conditions precluding TMS (epilepsy, pacemakers, metal implants etc.)
- •PD individuals excluded if they have atypical or secondary Parkinsonism. Additional neurological conditions (i.e. stroke, epilepsy etc. will also be exclusions)
- •Clinical diagnosis of depression, or a score of greater than 21 (21\-30 indicates moderate depression) as assessed through Beck’s Depression Inventory
Outcomes
Primary Outcomes
Not specified
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