The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia

Not Applicable

Completed

• Conditions: Spinocerebellar Ataxia
• Interventions: Other: Whole body vibration training

• Registration Number: NCT01983631
• Lead Sponsor: Chang Gung University

Brief Summary

The Cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input. The organization of vestibular and somato-sensory afferent informations are also reported to be impaired in patients with cerebellum dysfunctions. Ataxia and impaired balance control are common symptoms in individuals with spinocerebellar ataxia (SCA). Previous studies have shown that patient with cerebellar damage are usually agonist and antagonist muscle coordination problem. Past studies also found the regulation of reciprocal Ia inhibition was impaired in patients with spinaocerebellar ataxia. In chronic phase, weakness might be developed due to deconditioned. All deficits mentioned above might lead to a decrease functional ability. Therefore, increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal inhibition, and improve muscle strength might be able to improve the functional abilities of individuals with SCA.

Recently, whole body vibration (WBV) has been trained for health groups. Studies showed that WBV training were able to improve muscle strength, balance control, and functional ability. However, there is no evidence showed that whether the whole body vibration training can affect the brain and spinal cord for the regulation of neural circuits. Whether also can affect for maximal voluntary contraction and improve central fatigue. No previous studies that whole body vibration training for SCA.

Therefore, the purpose of this research was to investigate the intracortical facilitation and inhibition, reciprocal Ia inhibition, low frequency depression, maximal voluntary contraction, interpolated twitch technique to compare the different between the SCA and health subject. Also to investigate the short term and long term effect of WBV.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Status Verified: 2013-11
• Study First Submitted: 2013-11-07
• Study First Submitted QC: 2013-11-13
• Last Update Submitted: 2013-11-13
• Study First Posted: 2013-11-14
• Last Update Posted: 2013-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• Clinical diagnosis of spinocerebellar ataxia

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
WBV group	Whole body vibration training	Stage 1: Short-term Whole body vibration(3 minutes in half-squatting position)
training group	Whole body vibration training	Stage 2: Long-term WBV training (3 sessions per week for 4 weeks)

Primary Outcome Measures

Name	Time	Method
Muscle twitch force	Baseline, 4 weeks.	Measure of changes in muscle twitch force by interpolation twitch technique
Muscle voluntary activity level	Baseline, 4 weeks	Measure of changes in muscle voluntary activity level by interpolation twitch technique.
Balance	Baseline, 4 weeks	Measure of changes in berge balance scale and one-leg standing.
Severity of cerebellar ataxia	Baseline, 4 weeks	Measure of changes in international cooperative ataxia rating scale(ICARS).

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan