Randomized study on the effect of adjuvant radiotherapy with elective nodal irradiation on the antitumoral immune reaction of patients with head and neck carcinoma
- Conditions
- Cancer of the head and neck region
- Registration Number
- DRKS00034747
- Lead Sponsor
- Klinik und Poliklinik für Radioonkologie und Strahlentherapie, Universitätsmedizin Mainz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 20
Histopathological confirmation of hypopharyngeal, laryngeal, oral cavity or p16-negative oropharyngeal carcinomas
- Planned for postoperative radiotherapy following tumor resection and bilateral neck dissection
- Indication for adjuvant chemoradiotherapy after interdisciplinary discussion in the tumor board
- Performance status allows repeated blood draws
- Signed informed consent form
- Known genetic defects associated with reduced DNA damage repair (e.g. Werner syndrome, fanconi-anemia, ataxia teleangiectasia)
- lack of consent
- pregnancy. breastfeeding
- legal guardionship in health matters by third party
- severe mental illness
- no exposures to ionizing radiation that occurred less than 5 days before the start of RTx
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method