NL-OMON53357招募中不适用
Clarifying the Vascular Aspects of Dementia; natural history study - Vascular aspects in dementia: part 2
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet the
- •inclusion all of the following criteria. For this study three different routes
- •for inclusion exists. Inclusion criteria for each group separately are shown
- •1. Participants who were included in our previous CASCADE study (P19.039).
- •* Capable of giving informed consent (see appendix)
- •2. Patients who attended the memory clinic of the Leiden University Medical
- •Center/ Haaglanden MC within one year ago
- •Diagnosed with (mixed) probable AD
- •Diagnosed as MCI
- •Diagnosed as SCI
- •Age between 50-90 years
- •Capable of giving informed consent (see appendix)
- •3. Control subjects
- •Healthy adults without memory complaints
- •Age aged between 50-90 years old
- •Capable of giving informed consent
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study. For this study three different routes for
- •inclusion exists. Exclusion criteria for each group separately are shown below.
- •1. Participants who were included in our previous CASCADE study (P19.039).
- •No MRI at previous CASCADE study (P19.039)
- •2. Patients who attended the memory clinic of the Leiden University Medical
- •Center/Haaglanden MC within one year ago
- •- Contra-indication to MRI scanning:
- •Claustrophobia
- •Pacemakers and defibrillators
- •Nerve stimulators
- •Intracranial clips
- •Intraorbital or intraocular metallic fragments
- •Cochlear implants
- •Ferromagnetic implants
- •Hydrocephaluspump
- •Intra-utrine device (not all types)
- •Permanent make-up
- •Tattoos above the shoulders (not all)
- •- Specific contraindications to fMRI
- •Seizure within prior year.
- •Noncorrectable visual impairment.
- •- MMSE < 19 points (measured at moment of screening or at memory clinic with a
- •maximum of 6 months in retrospect) (this cutoff was also used in the Leiden
- •85-Plus study14)
- •- Severe physical restrictions (completely wheelchair dependent)
- •- Age above 90
- •3. Control subjects
- •- Contra-indication to MRI scanning:
- •Claustrophobia
- •Pacemakers and defibrillators
- •Nerve stimulators
- •Intracranial clips
- •Intraorbital or intraocular metallic fragments
- •Cochlear implants
- •Ferromagnetic implants
- •Hydrocephaluspump
- •Intra-utrine device (not all types)
- •Permanent make-up
- •Tattoos above the shoulders (not all)
- •- Specific contraindications to fMRI
- •Seizure within prior year.
- •Noncorrectable visual impairment.
- •- MMSE < 19 points (measured at moment of screening or at memory clinic with a
- •maximum of 6 months in retrospect) (this cutoff was also used in the Leiden
- •85-Plus study14)
- •- Severe physical restrictions (completely wheelchair dependent)
- •- Age above 90
研究者
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