NCT00567593已完成4 期
Gene Regulation by Thiazolidinediones
James Lewis1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2007年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- PDK4 mRNA
研究概览
简要总结
The purpose of this study is to determine the effect of rosiglitazone on the genes of the colon
详细描述
The primary aim of the study is to examine the effect of rosiglitazone (Avandia) on gene regulation in colonic epithelium in the absence of pathologic acute and chronic intestinal inflammation. The secondary aims are to determine the effect of rosiglitazone (Avandia) therapy on T cell activation and cytokine expression in the absence of pathologic acute and chronic intestinal inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Capable of giving informed consent
- •Agrees to use a barrier method of birth control for the duration of the study
排除标准
- •History of inflammatory bowel disease
- •Has taken prescription or over the counter medications in the two weeks prior to enrollment
- •History of diabetes, heart failure, angina, hypertension, coronary heart disease, cancer, bleeding disorder, HIV, AIDS
- •Fasting LDL >160 mg/dl
- •History of smoking in the year prior to enrollment
- •Pregnant or breastfeeding
研究组 & 干预措施
Rosiglitazone
Other
Rosiglitazone; 8mg tablet once a day for 14 days
干预措施: Rosiglitazone (Drug)
结局指标
主要结局
PDK4 mRNA
时间窗: 14 days
次要结局
未报告次要终点
研究者
James Lewis
Professor of Medicine and Epidemiology
University of Pennsylvania
研究点 (1)
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