The acute effects of testosterone administration in patients with pulmonary hypertensio
Phase 1
- Conditions
- Pulmonary Hypertension
- Registration Number
- EUCTR2004-003843-28-GB
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 0
Inclusion Criteria
Male and female patients over 18 years
Pulmonary hypertension diagnosed clinically > 1 month
Pulmonary hypertension diagnosed by right heart catheter (pulmonary artery pressure >25mmHg or 30mmHg with exercise)
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Cancer of prostrate or breast, PSA above normal range
Unable to lay flat e.g. spinal pathology
Mental incompetence
Pulmonary hypertension seondary to left sidd heart disease, pulmonary wedge pressure >18 mmHg
Pregnancy
Current participation in other research projects
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: Does testosterone improve pulmonary artey pressure an pulmonary vascular resistance;Secondary Objective: Does testosterone alter pulmonary capillary wedge pressure, right atrial pressure, right ventricular pressure, right ventricular pressure, cardiac index, mixed venous oxygen saturations, central venous pressure, systemic vascular resistance, pulse oximetry and blood pressure;Primary end point(s): Change in mean pulmonary artery pressure
- Secondary Outcome Measures
Name Time Method