The Impact of Timed Protein Supplementation to Maximize the Skeletal Muscle Adaptive Response to Resistance Type Exercise Training in Healthy Young Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Skeletal muscle fiber size
研究概览
简要总结
Resistance type exercise training has been shown to be a potent stimulus to increase skeletal muscle mass and strength in healthy men. Furthermore, timed protein intake is also known to affect the muscle adaptive response following exercise. Whether timed protein intake could augment the increase in muscle fiber size and/or satellite cell content following long-term exercise intervention remains to be established.
We hypothesize that protein supplementation before sleep, on both training and non-training days, during a 12 week resistance training program further increases type II muscle fibre cross sectional area when compared to the placebo group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 30 years
- •BMI between 18.5 and 30 kg/m2
- •Recreationally active, performing sports on a non-competitive basis between 2 and 5 hours p/wk
- •Participants willing and able to give written informed consent and to understand, to participate and to comply with the biomedical research project requirements
排除标准
- •HbA1C level above 6.5%
- •Fasted blood glucose level above 7 mmol/L
- •Serum creatinine level beneath 60 or above 120 µmol/L
- •Participants with a recent history or current state of COPD
- •Participants with a recent history or current state of rheumatoid arthritis
- •Participants with a recent history or current state of musculoskeletal/orthopedic disorders
- •Participants with a recent history or current state of renal disorder
- •Participants with a recent history or current state of cognitive impairment
- •Participants with orthopedic metal implants in the spine and/or upper/lower extremities
- •Participants with lactose intolerance and/or dairy protein allergy
- •Participants who are enrolled in an interventional biomedical research project or have received an investigational new drug or product with the last 30 days prior to screening.
- •Participants on medication, including anticoagulants
结局指标
主要结局
Skeletal muscle fiber size
时间窗: 12 weeks
Skeletal muscle fiber size will be assessed by muscle biopsy sampling before, during and after the 12 wks intervention period. Muscle fiber size will be expressed in µm2
次要结局
- Quadriceps cross-sectional area(12 weeks)
- Whole body en regional body composition(12 weeks)
- 1RM strength(12 weeks)