TAME Cardiac Arrest Trial. Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial

Phase 3

Completed

• Conditions: Postanoxic encephalopathy; brain injury after cardiac arest; 10007521; 10014623

• Registration Number: NL-OMON46761
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

1. Adult (age *18 years or older)
2. Out-of-hospital cardiac arrest of a presumed cardiac or unknown cause
3. Sustained ROSC * defined as 20 minutes with signs of circulation without the need for chest compressions
4. Unconscious (FOUR-score motor response of <4, not able to obey verbal commands after sustained ROSC)
5. Eligible for intensive care without restrictions or limitations
6. Within <180 minutes of ROSC

Exclusion Criteria

1. Unwitnessed cardiac arrest with an initial rhythm of asystole
2. Temperature on admission <30 C
3. On ECMO prior to ROSC
4. Obvious or suspected pregnancy
5. Intracranial bleeding
6. Severe chronic obstructive pulmonary disorder (COPD) with long-term home oxygen therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure for this study is the proportion of patients with a<br /><br>favourable neurological outcome at 6 months as assessed using the GOSE.</p><br>