NCT03671902
Completed
Not Applicable
Noninvasive Monitoring in Lower Body Negative and Positive Pressure Tests
ConditionsHemorrhage
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hemorrhage
- Sponsor
- Dartmouth-Hitchcock Medical Center
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Change in the phonocardiographic systolic index (PSI)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The goal of these studies is to assess the use of phonocardiograhy to monitor blood volume. We will evaluate phonocardiographic parameters in normal subjects in increasing levels of lower body negative pressure (LBNP) and lower body positive pressure (LBPP).
Investigators
James C. Leiter
Professor of Medicine
Dartmouth-Hitchcock Medical Center
Eligibility Criteria
Inclusion Criteria
- •At least 18 years old
- •Good health
- •Free of systemic diseases
- •No contraindications to LBNP/LBPP exposure
- •Normal resting systolic blood pressure (SBP, 100-140 mm Hg) and diastolic blood pressure (DBP, 60-90 mm Hg)
Exclusion Criteria
- •Pregnancy
- •Prior history of cardiovascular disease
Outcomes
Primary Outcomes
Change in the phonocardiographic systolic index (PSI)
Time Frame: Baseline, and at each incremental change of 5-10 mmHg up to 40 mm Hg. Total duration per arm is up to 45 min
Measuring changes in phonocardiographic parameters related to changes in blood volume
Study Sites (1)
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