NCT03671902已完成不适用
Noninvasive Monitoring in Lower Body Negative and Positive Pressure Tests
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Change in the phonocardiographic systolic index (PSI)
研究概览
简要总结
The goal of these studies is to assess the use of phonocardiograhy to monitor blood volume. We will evaluate phonocardiographic parameters in normal subjects in increasing levels of lower body negative pressure (LBNP) and lower body positive pressure (LBPP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 18 years old
- •Good health
- •Free of systemic diseases
- •No contraindications to LBNP/LBPP exposure
- •Normal resting systolic blood pressure (SBP, 100-140 mm Hg) and diastolic blood pressure (DBP, 60-90 mm Hg)
排除标准
- •Pregnancy
- •Prior history of cardiovascular disease
结局指标
主要结局
Change in the phonocardiographic systolic index (PSI)
时间窗: Baseline, and at each incremental change of 5-10 mmHg up to 40 mm Hg. Total duration per arm is up to 45 min
Measuring changes in phonocardiographic parameters related to changes in blood volume
次要结局
未报告次要终点
研究者
James C. Leiter
Professor of Medicine
Dartmouth-Hitchcock Medical Center
研究点 (2)
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