Reinforcement Learning and Obsessive-compulsive Disorder: Exploring the Role of the Orbitofrontal Cortex
- Conditions
- Obsessive-Compulsive Disorder
- Registration Number
- NCT06566781
- Lead Sponsor
- Fundacao Champalimaud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Exclusively for the OCD group: established diagnosis of Obsessive-Compulsive<br> Disorder according to DSM-5 criteria;<br><br> - Exclusively for the control group: does not meet DSM criteria for any of the<br> psychiatric diagnoses screened by the Mini International Neuropsychiatric Interview;<br><br> - Age between 18 and 65 years-old;<br><br> - Fluent Portuguese or English speaker.<br><br>Exclusion Criteria:<br><br> - Any acute medical illness;<br><br> - Substance abuse or dependence;<br><br> - Pregnancy;<br><br> - Dementia;<br><br> - Developmental disorders with low intelligence quotient or any other form of<br> cognitive impairment;<br><br> - Active neurological disease;<br><br> - Previously known structural lesion of the central nervous system;<br><br> - Illiteracy or otherwise not understanding the study's instructions;<br><br> - Inability to give informed consent;<br><br> - Individuals presenting with any psychotic or mood disorder condition requiring<br> hospitalization at that moment;<br><br> - For experiment 2, these exclusion criteria will be expanded by additional factors<br> that specifically preclude TMS use.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentration of high sensitivity C Reactive Protein (hsCRP).;Seropositivity for Group A Streptococcus (GAS).;Basal ganglia and orbito-frontal cortex (OFC) volume.;Exposure to childhood trauma as measured by the Childhood Trauma Questionnaire (CTQ).;Obsessive-compulsive symptom severity.;Measurement of fractional anisotropy (FA) in the brain white matter.;Functional connectivity of the orbitofrontal cortex (OFC).;Concentration of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG).;Model-free component in a computational model of a reinforcement learning behavioral task.
- Secondary Outcome Measures
Name Time Method Peripheral concentration of cytokines.;Peripheral concentration of transforming growth factor (TGF)-ß.;Presence of auto-antibodies.;Seropositivity for Toxoplasma gondii, Cytomegalovirus (CMV), Herpes simplex virus (HSV1 and HSV2).;Measurement of Neurite Orientation Dispersion and Density Imaging (NODDI) in the brain white matter.