A Gilead Sequence Registry of Subjects Who Did Not Achieve Sustained Virologic Response

Completed

• Conditions: Hepatitis C, Chronic

• Registration Number: NCT01457768
• Lead Sponsor: Gilead Sciences

Brief Summary

This Registry is designed to obtain long term data on participants who have failed to achieve sustained virologic response (SVR) while receiving at least one Gilead oral antiviral agent (OAV) in a previous Gilead-sponsored hepatitis C virus (HCV) study.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-10-04
• Study First Submitted QC: 2011-10-20
• Study First Posted: 2011-10-24
• Study Start: 2011-12-19
• Primary Completion: 2018-04-09
• Study Completion: 2018-04-09
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-03
• Last Update Posted: 2018-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 570

Inclusion Criteria

• Have previously participated in a Gilead-sponsored hepatitis C study and received at least one Gilead OAV
• Have failed to achieve an SVR in a previous Gilead-sponsored study, as defined in the original treatment protocol
• Provide written, informed consent
• Be willing and able to comply with the visit schedule

Key

Exclusion Criteria

• Individuals planning to start a new course of hepatitis C therapy including any investigational drug or device during the course of the follow-up Registry
• History of clinically significant illness or any other major medical disorder that may interfere with follow-up, assessments or compliance with the protocol

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of participants with at least one drug resistant mutation (DRM) loss from enrollment to end of study by treatment regimen	Up to 3 years

Secondary Outcome Measures

Name	Time	Method
Proportion of participants with DRM loss by unit category, 1, 2, 3,…n, by treatment regimen	Up to 3 years
Average number of DRM loss by treatment regimen	Up to 3 years
Liver disease progression	Up to 3 years	Liver disease progression is a composite endpoint measured by laboratory parameters (alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, albumin, platelets, prothrombin time (PT) and α-fetoprotein) and observed or reported clinical signs and symptoms.
Proportion of participants who develop hepatocellular carcinoma (HCC) through Week 144 by treatment regimen	Up to 144 weeks

Trial Locations

Locations (310)

Johns Hopkins University; 🇺🇸 Baltimore, Maryland, United States

University of Chicago; 🇺🇸 Chicago, Illinois, United States

Medical College of Wisconsin; 🇺🇸 Chicago, Illinois, United States

Northwestern Memorial Hospital; 🇺🇸 Chicago, Illinois, United States

California Liver Institute; 🇺🇸 Los Angeles, California, United States

Scripps Clinic; 🇺🇸 La Jolla, California, United States

Kaiser Permanente Institute for Health Research; 🇺🇸 La Jolla, California, United States

Advanced Clinical Research Institute, LLC; 🇺🇸 Anaheim, California, United States

Franco Felizarta, MD; 🇺🇸 Bakersfield, California, United States

eStudySite; 🇺🇸 Oceanside, California, United States

Digestive Health Specialists; 🇺🇸 Tupelo, Mississippi, United States

University of Arizona; 🇺🇸 Tucson, Arizona, United States

Southern California Medical Group; 🇺🇸 Coronado, California, United States

West Coast Clinical Trials, LLC; 🇺🇸 Costa Mesa, California, United States

VA Long Beach Healthcare System; 🇺🇸 Long Beach, California, United States

Kaiser Permanente of Colorado; 🇺🇸 Los Angeles, California, United States

Peter J. Ruane, MD, Inc.; 🇺🇸 Los Angeles, California, United States

8631 West 3rd Street; 🇺🇸 Los Angeles, California, United States

Veterans Administration Wadsworth Medical Center; 🇺🇸 Los Angeles, California, United States

Anthony Mills MD, Inc; 🇺🇸 Los Angeles, California, United States

Cedars-Sinai Medical Center; 🇺🇸 Los Angeles, California, United States

Stanford University; 🇺🇸 Palo Alto, California, United States

Digestive Healthcare of Georgia; 🇺🇸 Atlanta, Georgia, United States

660 South Fair Oaks Avenue; 🇺🇸 Pasadena, California, United States

San Jose Gastroenterology; 🇺🇸 San Jose, California, United States

Capital Medical Associates, P.C.; 🇺🇸 Washington, District of Columbia, United States

Pointe West Infectious Diseases d/b/a Bach and Godofsky Infectious Diseases; 🇺🇸 Bradenton, Florida, United States

Los Angeles BioMedical Institute at Harbor-UCLA Medical Center; 🇺🇸 Torrance, California, United States

Silicon Valley Research Institute; 🇺🇸 San Jose, California, United States

South Denver Gastroenterology; 🇺🇸 Englewood, Colorado, United States

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center; 🇺🇸 Torrance, California, United States

Whitman Walker Clinic; 🇺🇸 Washington, District of Columbia, United States

Advanced Research Institute; 🇺🇸 New Port Richey, Florida, United States

Atlanta Gastroenterology Associates; 🇺🇸 Atlanta, Georgia, United States

University of Kansas Medical Center Research Institute, Inc.; 🇺🇸 Kansas City, Kansas, United States

South Florida Center of Gastroenterology, P.A.; 🇺🇸 Wellington, Florida, United States

Gastrointestinal Specialists of Georgia, PC; 🇺🇸 Marietta, Georgia, United States

Emory University; 🇺🇸 Atlanta, Georgia, United States

Infectious Disease Specialists of Atlanta; 🇺🇸 Decatur, Georgia, United States

The Research Institute; 🇺🇸 Springfield, Massachusetts, United States

Medical Development Centers, LLC; 🇺🇸 Baton Rouge, Louisiana, United States

Lahey Clinic Medical Center; 🇺🇸 Burlington, Massachusetts, United States

Graves-Gilbert Clinic; 🇺🇸 Bowling Green, Kentucky, United States

Gastroenterology Associates, LLC; 🇺🇸 Baton Rouge, Louisiana, United States

Mercy Medical Center; 🇺🇸 Baltimore, Maryland, United States

Digestive Disease Associates, PA; 🇺🇸 Baltimore, Maryland, United States

Partners in Internal Medicine, PC; 🇺🇸 Worcester, Massachusetts, United States

Research Center at Affiliates in Gastroenterology; 🇺🇸 Morristown, New Jersey, United States

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States

ID Care, Inc.; 🇺🇸 Hillsborough, New Jersey, United States

Minnesota Gastroenterology, P.A.; 🇺🇸 Saint Paul, Minnesota, United States

Saint Louis University; 🇺🇸 Saint Louis, Missouri, United States

The Gastroenterology Group of South Jersey; 🇺🇸 Vineland, New Jersey, United States

St. Luke's Roosevelt Hospital; 🇺🇸 New York, New York, United States

North Shore University Hospital; 🇺🇸 Manhasset, New York, United States

Saint Michael's Medical Center; 🇺🇸 Newark, New Jersey, United States

University of New Mexico; 🇺🇸 Albuquerque, New Mexico, United States

Mount Sinai Beth Israel; 🇺🇸 New York, New York, United States

Asheville Gastroenterology Associates, P.A.; 🇺🇸 Asheville, North Carolina, United States

Southwest C.A.R.E. Center; 🇺🇸 Santa Fe, New Mexico, United States

Concorde Medical Group PLLC; 🇺🇸 New York, New York, United States

Weill Medical College of Cornell Univeristy; 🇺🇸 New York, New York, United States

Mount Sinai School of Medicine; 🇺🇸 New York, New York, United States

Binghamton Gastroenterology Associates; 🇺🇸 Johnson City, New York, United States

Columbia University Medical Center; 🇺🇸 New York, New York, United States

Saint Luke's-Roosevelt Hospital Center; 🇺🇸 New York, New York, United States

University of Rochester; 🇺🇸 Rochester, New York, United States

Options Health Research LLC; 🇺🇸 Tulsa, Oklahoma, United States

Westchester Medical Center; 🇺🇸 Yonkers, New York, United States

Schleinitz Research and Gastroenterology LLC; 🇺🇸 Medford, Oregon, United States

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States

UPMC Center For Liver Diseases; 🇺🇸 Pittsburgh, Pennsylvania, United States

Gastroenterology Center of the MidSouth, P.C.; 🇺🇸 Germantown, Tennessee, United States

Cumberland Research Associates, LLC; 🇺🇸 Fayetteville, North Carolina, United States

Texas Clinical Research Institute, LLC; 🇺🇸 Arlington, Texas, United States

Lehigh Valley Health Network, Network Office of Research and Innovation; 🇺🇸 Allentown, Pennsylvania, United States

Lehigh Valley Health Network; 🇺🇸 Allentown, Pennsylvania, United States

Regional Gastroenterology Associates of Lancaster, Ltd.; 🇺🇸 Lancaster, Pennsylvania, United States

Philadelphia FIGHT; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pennsylvania School of Medicine; 🇺🇸 Philadelphia, Pennsylvania, United States

Veterans Affairs Pittsburgh Healthcare System; 🇺🇸 Pittsburgh, Pennsylvania, United States

The Miriam Hospital; 🇺🇸 Providence, Rhode Island, United States

University Gastroenterology; 🇺🇸 Providence, Rhode Island, United States

Memphis Gastroenterology Group; 🇺🇸 Germantown, Tennessee, United States

Gastro One; 🇺🇸 Germantown, Tennessee, United States

The North Texas Research Institute; 🇺🇸 Arlington, Texas, United States

Nicholaos C. Bellos; 🇺🇸 Dallas, Texas, United States

Baylor University Medical Center; 🇺🇸 Dallas, Texas, United States

Digestive and Liver Disease Specialists; 🇺🇸 Norfolk, Virginia, United States

UT Southwestern Medical Center at Dallas; 🇺🇸 Dallas, Texas, United States

Methodist Transplant Physicians; 🇺🇸 Dallas, Texas, United States

Inova Fairfax Hospital Center for Liver Diseases; 🇺🇸 Falls Church, Virginia, United States

Metropolitan Research; 🇺🇸 Fairfax, Virginia, United States

Liver Institute of Virginia; 🇺🇸 Newport News, Virginia, United States

Greenslopes Private Hospital; 🇦🇺 Woolloongabba, Queensland, Australia

102 Burton Street; 🇦🇺 Darlinghurst, New South Wales, Australia

Canberra Specialist Centre; 🇦🇺 Canberra, Australian Capital Territory, Australia

Royal Prince Alfred Hospital; 🇦🇺 Camperdown, New South Wales, Australia

East Sydney Doctors; 🇦🇺 Darlinghurst, New South Wales, Australia

St Vincent's Public Hospital Sydney; 🇦🇺 Darlinghurst, New South Wales, Australia

Liverpool Hospital; 🇦🇺 Liverpool, New South Wales, Australia

Westmead Hospital; 🇦🇺 Westmead, New South Wales, Australia

Flinders Medical Centre; 🇦🇺 Bedford Park, South Australia, Australia

Footscray Hospital; 🇦🇺 Footscray, Victoria, Australia

Austin Health; 🇦🇺 Heidelberg, Victoria, Australia

University of Calgary; 🇨🇦 Calgary, Canada

University of Alberta; 🇨🇦 Edmonton, Canada

Alfred Hospital - Infectious Disease Unit; 🇦🇺 Melbourne, Victoria, Australia

Toronto Western Hospital; 🇨🇦 Toronto, Canada

Alfred Hospital; 🇦🇺 Melbourne, Victoria, Australia

LAIR Centre; 🇨🇦 Vancouver, Canada

St Vincent's University Hospital; 🇦🇺 Fitzroy, Australia

Toronto General Hospital; 🇨🇦 Toronto, Canada

Monash Medical Centre; 🇦🇺 Melbourne, Victoria, Australia

Royal Perth Hospital; 🇦🇺 Perth, Western Australia, Australia

Fiona Stanley Hospital; 🇦🇺 Murdoch, Western Australia, Australia

Royal Brisbane & Women's Hospital; 🇦🇺 QLD, Australia

Princess Alexandra Hospital; 🇦🇺 Woolloongabba, Australia

Medizinische Universität Graz; 🇦🇹 Graz, Styria, Austria

Vancouver Infectious Disease Research and Care Centre; 🇨🇦 Vancouver, British Columbia, Canada

Wilhelminenspital der Stadt Wien; 🇦🇹 Wien, Vienna, Austria

Inspiration Research Limited; 🇨🇦 Toronto, Ontario, Canada

Hopital Saint-Luc du CHUM; 🇨🇦 Montreal, Canada

Gordon & Leslie Diamond Health Care Centre; 🇨🇦 Vancouver, Canada

University of British Colombia; 🇨🇦 Vancouver, Canada

University of Manitoba, Health Sciences Center; 🇨🇦 Winnipeg, Canada

GIRI GI Research Institute; 🇨🇦 Vancouver, Canada

Remedis, s.r.o., Nestátní zdravotnické zarízení, Vladimírova 10; 🇨🇿 Praha 4, Czechia

West Tallinn Central Hospital; 🇪🇪 Talinn, Estonia

Tartu University Hospital; 🇪🇪 Tartu, Estonia

Hôpital Haut-Lévêque, CHU Bordeaux; 🇫🇷 Pessac Cedex, Aquitaine, France

Centre Hospitalier Universitaire de Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, Auvergne, France

Hôpital Henri Mondor; 🇫🇷 CRETEIL Cedex, Ile-de-france, France

Klinmed, s.r.o.; 🇨🇿 Praha 6, Czechia

Service Maladies Infectieuses; 🇫🇷 Paris Cedex 12, Ile-de-france, France

Hôpital Saint-Antoine; 🇫🇷 Paris cedex 12, Ile-de-france, France

CHU de Nancy; 🇫🇷 Vandoeuvre, France

Hôpital Bichat-Claude Bernard; 🇫🇷 Paris cedex 18, Ile-de-france, France

Hôpital La Pitié Salpétrière, Service des Maladies Infectieuses; 🇫🇷 Paris, Ile-de-france, France

Service des Maladies de l'Appareil Digestif et de la nutrition; 🇫🇷 Lille, NORD Pas-de-calais, France

Hôpital Claude Huriez- Service d'Hépato-Gastroentérologie; 🇫🇷 Lille, NORD Pas-de-calais, France

Hôpital-Saint Joseph, Service D'Hépato-Gastroentérologie; 🇫🇷 Marseille cedex 08, Provence Alpes COTE D'azur, France

Hôpital de I´Archet 2; 🇫🇷 Nice, Provence Alpes COTE D'azur, France

Centre Hospitalier Universitaire de Grenoble; 🇫🇷 Cedex 9, Rhone-alpes, France

Hopital Beaujon; 🇫🇷 clichy Cedex, France

Hopital Saint-Eloi; 🇫🇷 Montpellier, France

CHU de Nice - Hôpital l'Archet; 🇫🇷 Nice cedex 3, France

Hopital Pontchaillou; 🇫🇷 Rennes Cedex 9, France

Hôpital Saint Louis, Services des Maladies Infectieuses; 🇫🇷 Paris, France

Hopital Pitie-Salpetriere; 🇫🇷 Paris, France

C.H.U. Strasbourg - Hôpital Hautpierre - Hématologie; 🇫🇷 Strasbourg, France

Infektiologikum; 🇩🇪 Frankfurt am Main, Hessen, Germany

Albert-Ludwigs-Universität; 🇩🇪 Freiburg, Baden-wuerttemberg, Germany

Bertoldstrasse 48; 🇩🇪 Freiburg im Breisgau, Baden-wuerttemberg, Germany

Medizinische Universitätsklinik IV (Krehl Klinik) Abt. Gastroenterologie und Infektionskrankhen; 🇩🇪 Heidelberg, Baden-wuerttemberg, Germany

Universitätsklinikum Frankfurt; 🇩🇪 Frankfurt, Germany

CRC Hannover; 🇩🇪 Hannover, Niedersachsen, Germany

Medizinisches Versorgungszentrum; 🇩🇪 Düsseldorf, Nordrhein-westfalen, Germany

Universitätsklinikum Düsseldorf; 🇩🇪 Düsseldorf, Nordrhein-westfalen, Germany

Medizinisches Zentrum - Klinik für Gastroenterologie und Hepatologie; 🇩🇪 Essen, Nordrhein-westfalen, Germany

Gastroenterologische Gemeinschaftspraxis; 🇩🇪 Herne, Nordrhein-westfalen, Germany

Klinik für Gastroenterologie und Hepatologie am Abdominalzentrum; 🇩🇪 Köln, Nordrhein-westfalen, Germany

Leber- and Studienzentrum am Checkpoint; 🇩🇪 Berlin, Germany

Seestrasse 13; 🇩🇪 Berlin, Germany

MIB Dienstleistung GmbH; 🇩🇪 Berlin, Germany

Universitätsklinikum Bonn; 🇩🇪 Bonn, Germany

Asklepios Klinik St. Georg; 🇩🇪 Hamburg, Germany

Center for HIV and Hepatogastroenterology; 🇩🇪 Dusseldorf, Germany

Klinikum der Johann Wolfgang Goethe Universitaet; 🇩🇪 Frankfurt, Germany

Klinikum der Johann Wolfgang-Goethe-Universität; 🇩🇪 Frankfurt, Germany

Medizinische Universitatsklinik; 🇩🇪 Freiburg, Germany

Universitatsklinikum Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany

Institut für interdisziplinäre Medizin Studien GmbH an der Asklepiosklinik Saint Georg; 🇩🇪 Hamburg, Germany

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Germany

Klinikum der Universität Heidelberg; 🇩🇪 Heidelberg, Germany

Gastroenterologische Gemeinschaftspraxis Kiel; 🇩🇪 Kiel, Germany

Azienda Ospedaliera S. Orsola - Malpighi; 🇮🇹 Bologna, Italy

Mainz University; 🇩🇪 Mainz, Germany

Universitätsklinikum Würzburg - Med Klinik und Poliklinik; 🇩🇪 Wurzburg, Germany

Azienda Ospedaliera Papa Giovanni XXIII; 🇮🇹 Bergamo, Italy

Azienda Ospedaliera di Bologna - Policlinico S. Orsola Malpighi; 🇮🇹 Bologna, Italy

Ospedale San Raffaele-IRCCS, Centro San Luigi - San Raffaele Turro, Unità Operativa di Malattie Infettive; 🇮🇹 Milano, Italy

University of Leipzig; 🇩🇪 Leipzig, Germany

Johannes Gutenberg University Hospital; 🇩🇪 Mainz, Germany

Klinikum Innenstadt der LMU Munchen; 🇩🇪 Muenchen, Germany

Universitätsklinik Würzburg; 🇩🇪 Wüerzburg, Germany

Casa Sollievo della Sofferenza Hospital; 🇮🇹 San Giovanni Rotondo, Foggia, Italy

Ente Ospedaliero Ospedali Galliera di Genova; 🇮🇹 Genova, Italy

Azienda Ospedaliera; 🇮🇹 Milano, Italy

Dipartimento Polispecialistico - Malattie Infetive; 🇮🇹 Milano, Italy

Azienda Ospedaliera Ospedale Niguarda Ca' Granda; 🇮🇹 Milano, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; 🇮🇹 Milano, Italy

Azienda Ospedaliera Padova, U.O.C. Cardiologia; 🇮🇹 Padova, Italy

Azienda Ospedaliero Universitaria di Parma; 🇮🇹 Parma, Italy

Erasmus Medisch Centrum; 🇳🇱 Rotterdam, Zuid-holland, Netherlands

Universitair Medisch Centrum Sint Radboud; 🇳🇱 Nijmegen, Netherlands

Azienda Ospedaliera Città della Salute e della Scienza di Torino; 🇮🇹 Torino, Italy

Academisch Medisch Centrum; 🇳🇱 Amsterdam, Noord-holland, Netherlands

Leiden Universitair Medisch Centrum; 🇳🇱 Leiden, Zuid-holland, Netherlands

Auckland Clinical Studies Limited; 🇳🇿 Grafton, Auckland, New Zealand

Azienda Ospedaliera-universitaria Policlinico P. Giaccone; 🇮🇹 Palermo, Italy

Fondazione Policlinico Tor Vergata; 🇮🇹 Roma, Italy

Malattie Infettive - Epatologia; 🇮🇹 Roma, Italy

Middlemore Hospital; 🇳🇿 Grafton, Auckland, New Zealand

Auckland City Hospital; 🇳🇿 Grafton, Auckland, New Zealand

Bay of Plenty Clinical School; 🇳🇿 Tauranga, BAY OF Plenty, New Zealand

Urosurgery; 🇳🇿 Hamilton, New Zealand

Chattanooga Hem/Oncology Ass (SCRI); 🇵🇷 San Juan, Puerto Rico

Fundacion De Investigacion De Diego; 🇵🇷 San Juan, Puerto Rico

Hospital Universitario Nuestra Señora de Valme; 🇪🇸 Sevilla, Spain

Wellington Hospital; 🇳🇿 Wellington, New Zealand

Christchurch Hospital; 🇳🇿 Christchurch, New Zealand

SP ZOZ Wojewódzki Szpital Zakazny; 🇵🇱 Warszawa, Mazowieckie, Poland

C / Manuel de Falla; 🇪🇸 Majadahonda, Madrid, Spain

Waikato Hospital (District Health Board); 🇳🇿 Hamilton, New Zealand

Centrum Badan Klinicznych Osrodek Badan Wczesnej Fazy; 🇵🇱 Wroclaw, Dolnoslaskie, Poland

NZOZ Centrum Badan Klinicznych; 🇵🇱 Wroclaw, Dolnoslaskie, Poland

Clinical Research Puerto Rico; 🇵🇷 San Juan, Puerto Rico

Oddzial Dzienny; 🇵🇱 Warszawa, Mazowieckie, Poland

Wojewódzki Szpital Specjalistyczny im. Kazimierza Dluskiego w Bialymstoku; 🇵🇱 Bialystok, Podlaskie, Poland

Szpital Specjalistyczny w Chorzowie; 🇵🇱 Chorzów, Slaskie, Poland

SP ZOZ Wojewodzki Szpital Zakazny w Warszawie; 🇵🇱 Chorzow, Poland

Wojewodzki Specjalistyczny Szpital im. W. Bieganskiego; 🇵🇱 Lodz, Poland

ID Clinic; 🇵🇱 Myslowice, Slaskie, Poland

NZOZ Pol-SaNa-Med; 🇵🇱 Myslowice, Poland

Sahlgrenska Universitetssjukhuset, Östra Sjukhus; 🇸🇪 Göteborg, Sweden

Hospital Clinic I Provincial de Barcelona; 🇪🇸 Barcelona, Spain

Hospital Puerta de Hierro Majadahonda; 🇪🇸 Majadahonda, Madrid, Spain

Hospital General Universitario Gregorio Marañon; 🇪🇸 Madrid, Spain

Hospital Universitario La Paz; 🇪🇸 Madrid, Spain

Hospital General Universitario de Valencia; 🇪🇸 Valencia, Spain

Hospital Moncloa, Servicio de Enfermedades Infecciosas; 🇪🇸 Madrid, Spain

Avenida Tres Cruces s/n; 🇪🇸 Valencia, Spain

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Paseo de la Castellana nº 261; 🇪🇸 Madrid, Spain

Sahlgrenska Universitetssjukhuset, Östra sjukhuset; 🇸🇪 Göteborg, Vastra Gotaland, Sweden

Skånes Universitetssjukhus; 🇸🇪 Lund, Sweden

Karolinska Universitetssjukhuset Solna; 🇸🇪 Solna, Sweden

John Radcliffe Hospital; 🇬🇧 Oxford, England, United Kingdom

Westminster Bridge Road; 🇬🇧 London, England, United Kingdom

Skånes Universitetssjukhus i Lund; 🇸🇪 Lund, Sweden

Skånes Universitetssjukhus, Malmö; 🇸🇪 Malmö, Sweden

University of Birmingham and Queen Elizabeth Hospital Birmingham; 🇬🇧 Birmingham, England, United Kingdom

North Manchester General Hospital; 🇬🇧 Manchester, England, United Kingdom

Southampton University Hospitals NHS Trust, Southampton General Hospital; 🇬🇧 Hampshire, England, United Kingdom

St George Hospital; 🇬🇧 London, England, United Kingdom

Chelsea and Westminster Hospital NHS Foundation Trust; 🇬🇧 London, England, United Kingdom

Marlborough Street; 🇬🇧 Bristol, United Kingdom

Imperial College Healthcare NHS Trust; 🇬🇧 London, England, United Kingdom

Guy's and Saint Thomas NHS Foundation Trust; 🇬🇧 London, England, United Kingdom

King's College Hospital; 🇬🇧 London, England, United Kingdom

Derriford Hospital; 🇬🇧 Plymouth, United Kingdom

Queen's Medical Centre Campus; 🇬🇧 Nottingham, England, United Kingdom

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center; 🇺🇸 Boston, Massachusetts, United States

Community Research Initiative of New England; 🇺🇸 Boston, Massachusetts, United States

Harborview Medical Center; 🇺🇸 Seattle, Washington, United States

University of California San Diego; 🇺🇸 San Diego, California, United States

Research and Education, Inc.; 🇺🇸 San Diego, California, United States

Medical Associates Research Group, Inc.; 🇺🇸 San Diego, California, United States

University of Miami Miller School of Medicine; 🇺🇸 Miami, Florida, United States

Indianapolis Gastroenterology Research Foundation; 🇺🇸 Indianapolis, Indiana, United States

Therapeutic Concepts, PA; 🇺🇸 Houston, Texas, United States

Baylor College of Medicine; 🇺🇸 Houston, Texas, United States

St. Luke's Health Baylor College of Medicine Medical Center; 🇺🇸 Houston, Texas, United States

Indiana University School of Medicine; 🇺🇸 Indianapolis, Indiana, United States

St. Luke's Episcopal Hospital; 🇺🇸 Houston, Texas, United States

Impact Clinical Trials; 🇺🇸 Las Vegas, Nevada, United States

Kelsey Research Foundation; 🇺🇸 Houston, Texas, United States

Research Specialists of Texas; 🇺🇸 Houston, Texas, United States

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States

Alamo Medical Research; 🇺🇸 San Antonio, Texas, United States

The Texas Liver Institute; 🇺🇸 San Antonio, Texas, United States

California Pacific Medical Center; 🇺🇸 San Francisco, California, United States

University of California San Francisco; 🇺🇸 San Francisco, California, United States

Quest Clinical Research; 🇺🇸 San Francisco, California, United States

University of California, San Francisco School of Medicine; 🇺🇸 San Francisco, California, United States

San Francisco General Hospital; 🇺🇸 San Francisco, California, United States

Nashville Medical Research Institute; 🇺🇸 Nashville, Tennessee, United States

Nashville Gastrointestinal Specialists, Inc; 🇺🇸 Nashville, Tennessee, United States

Quality Medical Research, PLLC; 🇺🇸 Nashville, Tennessee, United States

Lifetree Clinical Research; 🇺🇸 Salt Lake City, Utah, United States

University of Utah Pediatric Pulmonology; 🇺🇸 Salt Lake City, Utah, United States

PRA Health Sciences; 🇺🇸 Salt Lake City, Utah, United States

Birmingham Gastroenterology Associates; 🇺🇸 Birmingham, Alabama, United States

University of Alabama at Birmingham; 🇺🇸 Birmingham, Alabama, United States

Henry Ford Health System; 🇺🇸 Detroit, Michigan, United States

Oregon Health & Science University; 🇺🇸 Portland, Oregon, United States

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States

200 1st st SW; 🇺🇸 Rochester, Minnesota, United States

UC Davis Medical Center; 🇺🇸 Sacramento, California, United States

Saint Joseph's Hospital; 🇺🇸 Tampa, Florida, United States

Tampa General Hospital; 🇺🇸 Tampa, Florida, United States

University of Colorado; 🇺🇸 Aurora, Colorado, United States

St. Joseph's Comprehensive Research Institute; 🇺🇸 Tampa, Florida, United States

Charite Campus Virchow-Klinikum; 🇩🇪 Berlin, Germany

Orlando Clinical Research Center; 🇺🇸 Orlando, Florida, United States

Yale University School of Medicine; 🇺🇸 New Haven, Connecticut, United States

Orlando Immunology Center-; 🇺🇸 Orlando, Florida, United States

Internal Medicine Specialists; 🇺🇸 Orlando, Florida, United States

Digestive Health Specialists, PA; 🇺🇸 Winston-Salem, North Carolina, United States

Liver Institute of Virginia, Bon Secours Health System; 🇺🇸 Richmond, Virginia, United States

Virginia Commonwealth University Medical Center; 🇺🇸 Richmond, Virginia, United States

Kansas City Gastroenterology and Hepatology; 🇺🇸 Kansas City, Missouri, United States

University of North Carolina at Chapel Hill; 🇺🇸 Chapel Hill, North Carolina, United States

University of Florida; 🇺🇸 Gainesville, Florida, United States

Austin Hospital; 🇺🇸 Austin, Texas, United States

Central Texas Clinical Research, LLC; 🇺🇸 Austin, Texas, United States

Wisconsin Hospital and Clinic; 🇺🇸 Madison, Wisconsin, United States

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States