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Clinical Trials/NCT00245232
NCT00245232
Completed
Not Applicable

Cognitive Processes in PTSD: Treatment

University of Missouri, St. Louis1 site in 1 country228 target enrollmentAugust 2000

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Post-Traumatic Stress Disorder
Sponsor
University of Missouri, St. Louis
Enrollment
228
Locations
1
Primary Endpoint
Depression symptoms; measured immediately post-treatment and 6 months post-treatment
Status
Completed
Last Updated
11 years ago

Overview

Brief Summary

This study will evaluate the effectiveness of cognitive processing therapy versus its individual components in treating women with post-traumatic stress disorder (PTSD) and depression brought on by sexual assault.

Detailed Description

PTSD is a psychiatric disorder that can occur following exposure to a traumatic event in which grave physical harm occurred or was threatened. PTSD is marked by clear biological changes as well as psychological symptoms. Many people with PTSD repeatedly relive the trauma in the form of flashback episodes, memories, nightmares, or frightening thoughts. This study will evaluate the effectiveness of cognitive processing therapy versus its individual components in treating women with post-traumatic stress disorder and depression brought on by sexual assault. Participants in this single-blind study will be randomly assigned to receive one of three treatments: cognitive processing therapy (CPT); cognitive therapy (CT); or written exposure (WE). Participants assigned to receive either CPT or CT will attend therapy sessions twice weekly for 6 weeks. CPT will focus on helping each individual to process accurate memories of the traumatic event and to work through any memories that cannot be completely ignored, nor completely integrated back into their thinking. Also included in CPT will be a WE component, in which participants will be encouraged to recall the traumatic event and experience any emotions connected to it. CT will be similar to CPT, but will not include the WE component. Participants assigned to receive only WE will attend one 2-hour session each week. Symptoms of PTSD and depression will be measured at baseline, post-treatment, and at a 6-month follow-up visit.

Registry
clinicaltrials.gov
Start Date
August 2000
End Date
April 2005
Last Updated
11 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Sponsor
University of Missouri, St. Louis

Eligibility Criteria

Inclusion Criteria

  • History of a discrete episode of assault in childhood or adulthood
  • Meets criteria for post-traumatic stress disorder

Exclusion Criteria

  • Experienced a traumatic event that was in the form of chronic ongoing abuse and not a discrete incidence
  • Psychosis
  • Mental retardation
  • Suicidal or parasuicidal
  • Currently addicted to drugs
  • Illiterate
  • Currently in an abusive relationship
  • Currently being stalked

Outcomes

Primary Outcomes

Depression symptoms; measured immediately post-treatment and 6 months post-treatment

Post-traumatic stress disorder symptoms; measured immediately post-treatment and 6 months post-treatment

Study Sites (1)

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