ISRCTN20609635进行中（未招募）未知
PRESSURE: PRotocolised Evaluation of permiSSive blood pressure targets versus Usual caRE. Evaluating the clinical and cost-effectiveness of using a permissive blood pressure target to guide titration of vasoactive drugs in critically ill children with hypotension
适应症
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 1,900
研究概览
简要总结
2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38629915/ (added 15/05/2024)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current participant inclusion criteria as of 11/08/2023:
- •1. Age >37 weeks corrected gestational age and <16 years
- •2. Enrolled within 6 hours of first meeting all the following criteria:
- •2.1. Accepted for or admitted to a participating PICU
- •2.2. Face-to-face contact with PICU staff or transport team
- •2.3. On invasive mechanical ventilation
- •2.4. Receiving a continuous infusion of vasoactive drug for hypotension
- •2.5. Vasoactive drug expected to continue for at least 6 hours or more
- •Previous participant inclusion criteria:
- •1. Age >37 weeks corrected gestational age and <16 years
- •2. Accepted for or admitted to PICU
- •3. Receiving a continuous infusion of a vasoactive drug for hypotension commenced within the previous 6 hours
- •4. Vasoactive drug expected to continue for at least 6 hours or more
- •5. On invasive mechanical ventilation
排除标准
- •Current participant exclusion criteria as of 11/08/2023:
- •1. Admitted post cardiac surgery
- •2. Known cardiomyopathy
- •3. Neonates with suspected or proven duct dependent circulation
- •4. Acute brain injury
- •5. Currently being treated for pulmonary hypertension
- •6. Admitted with malignant hypertension
- •7. Death perceived as imminent
- •8. Previously recruited to PRESSURE
- •Previous participant exclusion criteria:
- •1. Admitted post cardiac surgery
- •2. Known cardiomyopathy
- •3. Neonates with suspected or proven duct dependent circulation
- •4. Brain injury
- •5. Pulmonary hypertension
- •6. Malignant hypertension
- •7. Death perceived as imminent
- •8. Previously recruited to PRESSURE
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