Signatures of Response and Resistance to Mosunetuzomab in Follicular Lymphomas (FL)

Completed

• Conditions: Follicular Lymphoma

• Registration Number: NCT05529524
• Lead Sponsor: The Lymphoma Academic Research Organisation

Brief Summary

Mosunetuzumab is a T-cell bispecific antibody targeting CD20 and CD3 aiming to redirect T cells to engage and eliminate malignant B cells. Bispecific antibodies (BsAb) are a promising treatment option which can induce long-term responses in refractory and relapsed B cell lymphoma patients. However, the factors determining the quality and duration of responses are poorly understood.

Detailed Description

the objective is to produce a collection of great scientific interest for lymphoma research from CELESTIMO's clinical trial patients' samples to increase knowledge of treatment with mosunetuzumab's for patients with follicular lymphoma (FL).

study population involves patients participating to CELESTIMO study in France. 10 sites are expected in this biobanking protocol study

Biological samples will collected as part of routine care (tissue and blood already sampled in routine and/or CELESTIMO study) at screening, at C4, at C12 or at progressive disease/relapse.

Study Timeline

• Study First Submitted: 2022-09-02
• Study First Submitted QC: 2022-09-02
• Study First Posted: 2022-09-07
• Study Start: 2022-11-07
• Primary Completion: 2024-01-22
• Study Completion: 2024-01-22
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-23
• Last Update Posted: 2025-01-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Capacity of sampling	2 years	number of samples collected

Trial Locations

Locations (9)

Centre Hospitalier de La Cote Basque; Hematologie; 🇫🇷 Bayonne, France

Hopital Claude Huriez; Hematologie; 🇫🇷 Lille, France

CHU Saint Eloi; Service d'Hématologie Clinique; 🇫🇷 Montpellier, France

Institut Paoli Calmettes; 🇫🇷 Marseille, France

Hopital Saint Antoine; Hematologie Clinique; 🇫🇷 Paris, France

CHU NANTES - Hôtel Dieu; Service d'Hematologie Clinique; 🇫🇷 Nantes cedex 1, France

CHU de Nîmes - Hôpital Carémeau; 🇫🇷 Nîmes, France

Hopital De La Miletrie; Hematologie Et Oncologie Medicale; 🇫🇷 Poitiers, France

CHU Pontchaillou; 🇫🇷 Rennes, France