NCT05182619Unknown1 期
Ultrasound-guided Stellate Ganglion Block Versus Nimodipine Infusion for Enhancement of Cerebral Blood Flow in Traumatic Brain Injury
适应症
干预措施
试验速览
- 阶段
- 1 期
- 入组人数
- 60
- 主要终点
- enhancement of cerebral blood flow
研究概览
简要总结
the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients more than 18 ys old with isolated head trauma and traumatic brain injury
排除标准
- •• Hemodynamic instability (mean ABP less than 70 mmHg)
- •History of severe systemic disease including cardiopulmonary failure or hepatorenal failure
- •Allergy to local anesthetics
- •Coagulation disorders
- •Abnormal neck structures disturbing normal anatomy as neck tumors
研究组 & 干预措施
ultrasoung guided stellate block
Active Comparator
stellate ganglion will have ultrasound-guided block via bupivacaine for sympathectomy and enhancement of cerebral blood flow
干预措施: ultrasound-guided stellate ganglion block (Procedure)
nimodipine infusion
Active Comparator
intravenous nimodipine will be given for enhancement of cerebral blood flow
干预措施: ultrasound-guided stellate ganglion block (Procedure)
结局指标
主要结局
enhancement of cerebral blood flow
时间窗: one week
increased blood flow through middle cerebral artery and basilar artery measured by transcranial doppler ultraound
次要结局
未报告次要终点
研究者
Khaled Mohamed Abdelaal
assistant lecturer os anesthesia and intensive care
Sohag University
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