Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury

Early Phase 1

• Conditions: Traumatic Brain Injury
• Interventions: Procedure: ultrasound-guided stellate ganglion block

• Registration Number: NCT05182619
• Lead Sponsor: Sohag University

Brief Summary

the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-12
• Study First Submitted: 2021-12-20
• Study First Submitted QC: 2021-12-20
• Last Update Submitted: 2021-12-20
• Study Start: 2022-01-01
• Study First Posted: 2022-01-10
• Last Update Posted: 2022-01-10
• Primary Completion: 2023-01-01
• Study Completion: 2023-04-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• patients more than 18 ys old with isolated head trauma and traumatic brain injury

Exclusion Criteria

• • Hemodynamic instability (mean ABP less than 70 mmHg)

  • History of severe systemic disease including cardiopulmonary failure or hepatorenal failure
  • Allergy to local anesthetics
  • Coagulation disorders
  • Abnormal neck structures disturbing normal anatomy as neck tumors

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ultrasoung guided stellate block	ultrasound-guided stellate ganglion block	stellate ganglion will have ultrasound-guided block via bupivacaine for sympathectomy and enhancement of cerebral blood flow
nimodipine infusion	ultrasound-guided stellate ganglion block	intravenous nimodipine will be given for enhancement of cerebral blood flow

Primary Outcome Measures

Name	Time	Method
enhancement of cerebral blood flow	one week	increased blood flow through middle cerebral artery and basilar artery measured by transcranial doppler ultraound