ACTRN12619001440112已完成3 期
Effect of metformin on hepatic and peripheral insulin resistance in adults with type 1 diabetes: protocol of a double-blind placebo controlled, randomised trial
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 20 Years 至 55 Years（—）
- 性别
- All
入选标准
- •T1D and controls without diabetes:
- •1. Age: adult (ages 20-55)
- •2. Premenopausal (if female)
- •1. < 10 years since diagnosis of diabetes
- •2. Fasting c-peptide < 0.3nmol/L)
- •3. HbA1c less than or equal to 9.5%
排除标准
- •1. Current smoking
- •2. Current or planned prescription of medications that affect glucose metabolism (glucocorticoids, antipsychotics, immunosuppressants).
- •3. Exposure to metformin within the last 30 days
- •4. Alcohol intake > 20g/day in women or > 40g/day in men
- •5. Weight change > 5% in last 3 months or history of bariatric surgery
- •6. Pregnancy, breastfeeding, or childbearing potential not willing to avoid pregnancy during the study
- •7. Known major organ dysfunction (eGFR < 60, liver disease transaminases > 3 times the upper limit of normal, cardiac event within the last 6 months, current cancer or uncontrolled thyroid dysfunction).
- •8. Diabetic ketoacidosis or severe hypoglycaemia (hypoglycaemia requiring third-party assistance) in the last 6 months.
- •9. A history of a psychological illness or condition that would interfere with the patient’s ability to understand the requirements of the study.
研究者
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