Microbiological etiology of community acquired pneumonia in immunocompromised adults.
- Conditions
- Lower Respiratory Tract InfectionPneumonia1002497010004018
- Registration Number
- NL-OMON44107
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1400
For the 1000 CAP patients:
Immunocompromised patients, aged 18 years or older with suspicion of CAP defined as the presence of at least two of the following symptoms: fever/ hypothermia, cough, sputum production, dyspnea/ tachypnea/ hypoxia, percussion/ auscultatory findings consistent with pneumonia, leucocytosis/ leukopenia/ left shift or new infiltrate on chest X-ray. ;For the 400 controls:
Adults (18 years or older) with an immune-compromising condition, and able to provide urine.
For the 1000 CAP patients:
- Patients with recent hospitalization (<2 weeks)/ residing in long-term care facilities.
- CAPiTA participants.;For the 400 controls:
- Subjects with suspicion of CAP or other respiratory infectious diseases, as well as evidence of or documented concomitant infectious disease within 14 days of the day of inclusion.
- Subjects with fever (measured temperature of *38.0°C measured by a healthcare provider).
- Subjects residing in any long-term care facilities (for example, nursing homes, respite care facilities, etc.).
- Subjects with either pneumococcal conjugate vaccine (PCV) and/or pneumococcal polysaccharide vaccine (PPV) administration within the past 30 days.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To quantify the microbiological etiology in immunocompromised patients, at<br /><br>least 18 years of age, with CAP needing hospitalization.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To determine the severity, antibiotic use and outcome of CAP in<br /><br>immunocompromised patients, at least 18 years of age, with CAP needing<br /><br>hospitalization. </p><br>