Is wGRS Associated With DD Recurrence?

Completed

• Conditions: Dupuytren Contracture

• Registration Number: NCT02983162
• Lead Sponsor: University Medical Center Groningen

Brief Summary

Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence. However, a significant dose-response relation was not found. This might be caused by underestimating the recurrence rate, due to the retrospective nature of determining recurrence. Therefore, we want to do a follow-up measurement of the GODDAF participants, to see whether they suffered from recurrent disease.

Objective: We aim to determine whether the wGRS is associated with recurrent DD.

Study design: An observational study, in which the participants of the GODDAF study are followed up.

Study population: Patients affected by Dupuytren disease, aged 18-96 years, who were previously included in another study on the genetic basis of Dupuytren disease.

Intervention (if applicable): NA Main study parameters/endpoints: The main study parameter is the presence of recurrent Dupuytren disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-12-02
• Study First Submitted QC: 2016-12-05
• Study First Posted: 2016-12-06
• Study Start: 2017-03-10
• Primary Completion: 2018-08-01
• Study Completion: 2018-08-01
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-09
• Last Update Posted: 2022-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 427

Inclusion Criteria

• DD patient
• participant in the GODDAF study
• genetic data passed the quality control
• surgical treatment of DD
• written informed consent

Exclusion Criteria

• Decisionally incapacitated
• Patients treated for DD with collagenase or radiotherapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of recurrent Dupuytren disease	1 day	there is only one measurement in this study

Secondary Outcome Measures

Name	Time	Method
Severity of Dupuytren recurrence	1 day	there is only one measurement in this study

Trial Locations

Locations (1)

University Medical Center Groningen, dept Plastic Surgery; 🇳🇱 Groningen, Netherlands