Personalized Precision Diagnosis and Treatment of High-grade Serous Ovarian Carcinoma During the Perioperative Period Assisted by Multi-omics and Artificial Intelligence Models, and Research on the Heterogeneity of Immune Microenvironment
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,300
- 主要终点
- Disease-free survival
研究概览
简要总结
The subjects of this study are patients with high-grade serous ovarian cancer who have undergone surgical resection. The aim is to construct an artificial intelligence model for predicting postoperative recurrence, metastasis and overall survival of patients based on multimodal data such as surgical pathological images (HE images and IHC images of immune microenvironment-related markers), preoperative baseline imaging data and detailed clinical information of patients. In addition, multi-omics sequencing analysis will be used to deeply explore the heterogeneity of the tumor microenvironment, with the expectation of quantifying the postoperative recurrence risk of patients with high-grade serous ovarian cancer and providing new ideas for the precise diagnosis and treatment of patients with high-grade serous ovarian cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed high-grade serous ovarian carcinoma using resection specimens.
- •Well-preserved surgical paraffin-embedded tumor specimens.
- •Complete clinical information and survival follow-up data.
排除标准
- •Received preoperative neoadjuvant treatment.
- •Poor preservation of surgical paraffin specimens.
- •Incomplete clinical information and survival follow-up data.
- •With concurrent malignancies other than high-grade serous ovarian carcinoma.
研究组 & 干预措施
High-Risk Group of Recurrence or Metastasis
AI-assisted patients who have high-risk of postoperative recurrence or metastasis.
干预措施: No Intervention: Observational Cohort (Other)
Low-Risk Group of Recurrence or Metastasis
AI-assisted patients who have low-risk of postoperative recurrence or metastasis.
干预措施: No Intervention: Observational Cohort (Other)
结局指标
主要结局
Disease-free survival
时间窗: through study completion, an average of 1 year
次要结局
未报告次要终点