Measuring bone growth in bony defects caused by periodontal diseases after treating with growth factors found in blood along with artificial bone powder.
- Conditions
- Chronic periodontitis,
- Registration Number
- CTRI/2019/01/017043
- Lead Sponsor
- Rajarajeswari Dental College and Hospital
- Brief Summary
Concentrated growth factors (CGFs) are a new generation of platelet concentrates, which contain abundant growth factors.
CGF is produced by the centrifugation of venous blood, and platelets are concentrated in a gel layer containing ï¬brin matrix as same as Platelet-Rich-Fibrin (PRF). However, a different centrifugation speed permits the isolation of much larger, denser and richer Growth Factors (GFs) in ï¬brin matrix from CGF. This ï¬brin clot has a high cohesion because of the agglutination of ï¬brinogen, factor XIII and thrombin. This provides protection from plasmin degradation, resulting in higher ï¬brin tensile strength and stability.
This study aims at evaluating and comparing the efficacy and regenerative potential of CGF and CGF in combination with bioactive glass in the treatment of furcation defects.
36 molar furcation defects in patients with chronic periodontitis will be grouped into 3 categories.
Following administration of LA, a full thickness flap will be reflected and granulation tissue will be removed. Following debridement, the furcation defect will be filled using appropriate graft material.
Group I patients will receive CGF.
Group II patients will receive CGF mixed with bioactive glass.
Group III patients will undergo an open flap debridement only.
Clinical and radiological parameters will be recorded at baseline, 6 months and 9 months post-operatively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 36
Presence of Grade II furcation defects (Glickman’s classification) in mandibular molars, with a radiolucency in the furcation area, with a probing depth (PD) ≥5mm and horizontal PD ≥3mm.
- 1.Patients with systemic illness known to affect the outcomes of periodontal therapy.
- 2.Patients on any medication taken within the last 6 months which may alter the periodontal status.
- 3.Individuals allergic to medications.
- 4.Pregnant or lactating women.
- 5.Chronic smokers and alcoholics.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 2.Vertical probing depth Baseline | 6 months | 9 months 1.Horizontal measurement of the furcation defect Baseline | 6 months | 9 months 3.Radiographic defect depth Baseline | 6 months | 9 months
- Secondary Outcome Measures
Name Time Method Gingival index Plaque index
Trial Locations
- Locations (1)
Rajarajeswari Dental College and Hospital
🇮🇳Rural, KARNATAKA, India
Rajarajeswari Dental College and Hospital🇮🇳Rural, KARNATAKA, IndiaThaslim Fathima NPrincipal investigator9620094215thaslimfathima93@gmail.com