Integrative Analysis of CRC Liver Metastasis
Recruiting
- Conditions
- Metastasis
- Interventions
- Other: normal colorectal tissues
- Registration Number
- NCT02917707
- Lead Sponsor
- Da Fu
- Brief Summary
The investigators will perform integrative analysis of CRC liver metastasis
- Detailed Description
The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
- Age ≤ 75 years with histologically proven CRC
- No severe major organ dysfunction
- WHO performance status of 0 or 1
- No prior cancer chemotherapy
Exclusion Criteria
- Age ≥ 76
- Severe major organ dysfunction
- World Health Organization (WHO) performance status of >1
- Prior cancer chemotherapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description normal colorectal tissues (PN) normal colorectal tissues normal colorectal tissues primary colorectal carcinoma tissues normal colorectal tissues primary colorectal carcinoma tissues liver metastasis tissues normal colorectal tissues liver metastasis tissues
- Primary Outcome Measures
Name Time Method 5 years overall survival 5 years
- Secondary Outcome Measures
Name Time Method 5 years disease-free survival 5 years
Trial Locations
- Locations (2)
Ganzhou City People's Hospital
🇨🇳Ganzhou, Jiangxi, China
Shanghai Tenth People's Hospital
🇨🇳Shanghai, Shanghai, China