NCT02917707招募中不适用
Integrative Analysis of CRC Liver Metastasis
Da Fu2 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2016年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- 5 years overall survival
研究概览
简要总结
The investigators will perform integrative analysis of CRC liver metastasis
详细描述
The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≤ 75 years with histologically proven CRC
- •No severe major organ dysfunction
- •WHO performance status of 0 or 1
- •No prior cancer chemotherapy
排除标准
- •Severe major organ dysfunction
- •World Health Organization (WHO) performance status of >1
- •Prior cancer chemotherapy
结局指标
主要结局
5 years overall survival
时间窗: 5 years
次要结局
- 5 years disease-free survival(5 years)
研究者
Da Fu
Principal Investigator
Shanghai 10th People's Hospital
研究点 (2)
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