Evaluation of the anti-cariogenic effect of chitosan–nano amorphous calcium phosphate and chitosan-nano hydroxyapatite varnish around orthodontic brackets; A Randomized clinical trial

Shiraz University of Medical Sciences0 个研究点目标入组 120 人开始时间: 待定最近更新: 2022年3月8日

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•Patients aged 14-29 years old who require fixed orthodontic therapy
•All maxillary permanent teeth present up to at least first molars
•Good overall health
•Good oral hygiene ( with plaque score =20% )
•No visible discontinuous band of plaque at the gingival margin of teeth and no bleeding on probing after 30 seconds
•Normal stimulated salivary flow rate (>1.0 mL /min) and buffer capacity ( a final pH of 6.0 and 7.0)

•History of any previous orthodontic treatments or extractions
•History of using any bleaching agents or topical fluoridation within the last six months
•Non-observence of oral hygiene instructions
•Sever crowding of >6mm or severely rotated teeth , necessitating extraction of teeth
•Blocked out teeth and high buccal teeth that ristricts the patient hygienic access also put limitation for vissual and diagnodent examinations
•Any dental morphologic anomaly,intrinsic or extremly heavy extrinsic staining
•Visible signs of caries or fluorosis or hypocalcification and also any developmental defects
•Existence of dental crowns, amalgam or composite restorations which extended to buccal surface of teeth
•Any systemic or endocrine problems ( such as diabetes or cardiovascular diseases), craniofacial anomalies and lip or palatal clefts and smoking habits
•Any WSLs present on qualified teeth with and without frank cavitation, alterations of the enamel, e.g. hypoplasia, fluorosis
•Chronic use of medication causing a dry mouth or known xerostomia; known pregnancy or breastfeeding during the course of the study
•Professional administration or home use of highly concentrated fluoride products not related to the study during the whole study

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