nderstanding standing in Postural Orthostatic Tachycardia Syndrome (POTS)

Not Applicable

• Conditions: Postural Orthostatic Tachycardia Syndrome; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12624000393550
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-04-03
• Last Update Posted: 8 April 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

•Participants with a clinical diagnosis of POTS
•Healthy volunteers with no history of POTS
•Men and women
•Aged 18 years and over

Exclusion Criteria

•Severe cardiac disease (e.g., coronary artery disease, heart failure, hypertension)
•Primary / secondary autonomic dysfunction
•Significant arrhythmias (e.g., atrial fibrillation, previous VT / significant ventricular ectopy)
•Severe respiratory disease (e.g., chronic obstructive pulmonary disease)
•Severe, uncontrolled type II diabetes
•Significant renal or liver disease
•Significant neurological disease including diabetic neuropathy
•Current active treatment for cancer
•Inflammatory disease
•Infection or pyrexial illness
•Uncontrolled thyroid disorders
•Recent (< 3 months) ischemic stroke
•Current smoker/vaper
•Current pregnancy
•Users of recreational drugs
•Current hazardous alcohol use. Participant’s alcohol intake will be initially screened in the Health Screening Questionnaire. If alcohol intake exceeds recommended limits, then the participant will be assessed by AUDIT questionnaire for hazardous alcohol intake (score of 8 or more on AUDIT).
•Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterial stiffness[Pulse wave velocity and pulse wave analysis using applanation tonometry (Sphygmocor) Assessed once at a single time-point (Experimental visit 1)];Endothelial function[Flow-mediated dilatation using Doppler ultrasound Assessed once at a single time-point (Experimental visit 1)];Venous function[Venous occlusion plethysmography Assessed once at a single time-point (Experimental visit 2)]

Secondary Outcome Measures

Name	Time	Method
Heart rate[Electrocardiogram Assessed continuously for ~2 hours during Experimental visit 2];Blood pressure[Finger photoplethysmography Assessed continuously for ~2 hours during Experimental visit 2];Muscle sympathetic nerve activity[Microneurography Assessed continuously for ~2 hours during Experimental visit 2]