Skip to main content
MedPath Trial logoMedPath TrialMedPath Trial Home
Clinical Trials/NCT03088163
NCT03088163UnknownNot Applicable

The Value of DWI-MRI(Diffusion-weighted Imaging) in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer

Fudan University1 site in 1 country100 target enrollmentStarted: August 2016Last updated:
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
Conditions

Trial Snapshot

Phase
Not Applicable
Enrollment
100
Locations
1
Primary Endpoint
Response rate
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Device Feasibility
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •aged ≥18 years with histologically or cytologically confirmed advanced colorectal adenocarcinoma
  • •Eastern Cooperative Oncology Group performance status of 0 to 2
  • •life expectancy of ≥ 3 months
  • •at least one measurable liver metastatic lesion in MRI (≥10mm)
  • •have adequate bone marrow, hepatic, and renal function
  • •previously received no palliative chemotherapy

Exclusion Criteria

  • •patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction
  • •patients with symptomatic brain metastases
  • •active clinical severe infection
  • •have contraindication of MRI screening

Outcomes

Primary Outcomes

Response rate

Time Frame: 2 months

the response rate predicted by DWI-MRI

Secondary Outcomes

  • Progression free survival(2 months)
  • Overall survival(2 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Weijian Guo

Fudan University Shanghai Cancer Center

Fudan University

Study Sites (1)

Loading locations...

Similar Trials

Completed
Not Applicable
Diagnostic Value of DWI-MRI for Detection of Peritoneal Metastases in High-risk Pancreatic Ductal Adenocarcinoma.Pancreas Cancer, Duct Cell AdenocarcinomaPancreas AdenocarcinomaPeritoneal MetastasesPeritoneal Carcinomatosis
NCT05340569Laval University40
Active, not recruiting
Not Applicable
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal NeoplasmsPeritoneal CarcinomatosisPeritoneal MetastasesAppendix CancerAppendix NeoplasmColorectal Cancer
NCT05623787Laval University30
Unknown
Not Applicable
DCE-MRI and DWI for Detection and Diagnosis of Breast CancerBIRADS 3BIRADS 4BIRADS 5Breast Cancer
NCT02022579American College of Radiology Imaging Network100
Completed
Not Applicable
Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary LesionsThorax Cancer
NCT02482181ÇAĞLAYAN ÇAKIR46
Completed
Not Applicable
A PILOT STUDY OF DIFFUSION WEIGHTED MRI TO ASSESS ESOPHAGEAL TUMOR RESONSE TO NEOADJUVANT CHEMORADIATIONEsophageal Cancer
NCT03151642Abramson Cancer Center at Penn Medicine11