The Value of Diffusion-weighted Imaging in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer
Not Applicable
- Conditions
- DWI-MRI
- Interventions
- Device: Diffusion weighted magnetic resonance imaging
- Registration Number
- NCT03088163
- Lead Sponsor
- Fudan University
- Brief Summary
The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- aged ≥18 years with histologically or cytologically confirmed advanced colorectal adenocarcinoma
- Eastern Cooperative Oncology Group performance status of 0 to 2
- life expectancy of ≥ 3 months
- at least one measurable liver metastatic lesion in MRI (≥10mm)
- have adequate bone marrow, hepatic, and renal function
- previously received no palliative chemotherapy
Exclusion Criteria
- patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction
- patients with symptomatic brain metastases
- active clinical severe infection
- have contraindication of MRI screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description DWI-MRI Diffusion weighted magnetic resonance imaging -
- Primary Outcome Measures
Name Time Method Response rate 2 months the response rate predicted by DWI-MRI
- Secondary Outcome Measures
Name Time Method Progression free survival 2 months Overall survival 2 months
Trial Locations
- Locations (1)
Fudan University Cancer Hospital
🇨🇳ShangHai, Shanghai, China