Utrasound of the eye to detect raised intracranial pressure

Recruiting

• Conditions: Disorder of brain, unspecified,

• Registration Number: CTRI/2020/04/024567
• Lead Sponsor: Fortis Memorial Research institute

Brief Summary

1. Various studies have investigated Optic nerve sheath diameter (ONSD) as a marker for elevated intracranial pressure (ICP) and have found good correlation between the two. Further, ONSD diameter as measured by bedside ultrasonography, has been found to be well correlated with that measured with the help of MRI images.

2. To the best of our knowledge, there is paucity of Indian studies which show correlation between the ONSD values as measured by ultrasonography and the signs of raised ICP on neuroimaging modalities (CT/MRI scans).



**AIMS & OBJECTIVES**

1. To determine the normal optic nerve sheath diameter measured by bedside ultrasonography in the Indian population

2. To study the correlation of optic nerve sheath diameter measured by bedside ultrasonography and the features of raised intracranial pressure on neuroimaging.

3. To determine optimal cut off point of optic nerve sheath diameter to detect raised intracranial pressure

**METHODOLOGY**

Linear ultrasound probe will be used to measure the ONSD as the outer limits of the 2 hyperechoic lines, using electronic callipers, 3mm behind the papilla.

ONSD cut-off of 5mm will be used to define the presence of intracranial hypertension.

Patients with any one of the following findings on neuroimaging will be considered to have raised intracranial pressure-

1. Midline shift > 3mm

2. Sulcal effacement with significant oedema

3. Compression of third ventricle

4. Hydrocephalus

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-16
• Last Update Posted: 2021-04-07

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• 1.Age > 18 years 2.Patient with clinical features of raised ICP such as headache, vomiting, blurring of vision, altered sensorium, GCS<13.
• 3.Moderate to severe traumatic brain injury (Glasgow coma scale <13) 4.Progressive neurological deterioration since admission 5.History of active malignancy with new onset confusion.

Exclusion Criteria

1.Age <18 years 2.Orbital trauma 3.Orbital mass.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the correlation of optic nerve sheath diameter measured by bedside ultrasonography and the features of raised intracranial pressure on neuroimaging.	Baseline

Secondary Outcome Measures

Name	Time	Method
To determine the normal optic nerve sheath diameter by bedside ultrasonography in the Indian population.	2 years
To determine optimal cut off point of optic nerve sheath diameter to detect raised intracranial pressure	2 years

Trial Locations

Locations (1)

Fortis Memorial Research Institute; 🇮🇳 Gurgaon, HARYANA, India

Fortis Memorial Research Institute

🇮🇳Gurgaon, HARYANA, India

Dr Apoorv Jain

Principal investigator

9999653544

apoorvjain16@gmail.com