The effect of two topical drugs fluorouracil 5% and niacin amide 1% in the treatment of patients with actinic keratosis

Phase 2

Recruiting

• Conditions: Actinic keratosis.; Actinic keratosis; L57.0

• Registration Number: IRCT20220519054920N1
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

New patients with actinic keratosis who have not yet received any medication
Patients who have previously received topical medication and have not received topical medication in at least one month
People aged 18 and over
Non-hyperkeratotic lesions

Exclusion Criteria

Existence of other skin diseases at the treatment site
History of hypersensitivity to fluorouracil or niacin acid
Pregnant and lactating women

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvment rate. Timepoint: Before and after intervention. Method of measurement: Scoring based on the opinion of two dermatologists.;Dermoscopic grading. Timepoint: Before and after intervention. Method of measurement: Based on scoring by two dermatologist.;Complications of treatment. Timepoint: Weeks 4 and 8 in the fluorouracil group and weeks 6 and 12 in the niacinamid group. Method of measurement: Asking the patients.