Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis

Completed

• Conditions: Hydronephrosis
• Interventions: Procedure: dismembered pyeloplasty

• Registration Number: NCT01839006
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (\> 55%) in the DTPA renography will be analyzed.

Detailed Description

To assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (\> 55%) in the DTPA renography will be analyzed. Clinical parameters including age at the first visit, age at operation, gender, laterality, and follow-up period will be evaluated. To evaluate predictors of recovery from supranormal renal function according to the level of DRF, univariate and multivariate logistic regression analyses will be performed. Patients would be subcategorized into two groups; group A (DRF ≤60%) and group B (DRF \>60%) in consideration of the mean value of preoperative DRF and each parameter of group A was compared to that of group B using independent sample's t test and chi square test. Kaplan-Meier analysis and log-rank test will be used to determine the difference of recovery time of obstructed hydronephrosis in each parameter.

Study Timeline

• Study Start: 2011-06
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Study First Submitted: 2011-06-25
• Status Verified: 2013-04
• Study First Submitted QC: 2013-04-21
• Last Update Submitted: 2013-04-21
• Study First Posted: 2013-04-24
• Last Update Posted: 2013-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• ureteropelvic junction obstruction
• hydronephrosis
• differential renal function more than 55% in DTPA
• follow-up period more than 1 year

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Exclusion Criteria

• urological anomalies, such as vesicoureteral reflux, ureterocele, cystic kidney disease, posterior urethral valves, duplex anomalies, neurogenic bladder, and solitary kidney or patients who underwent any previous urological surgery

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with supranormal renal function	dismembered pyeloplasty	Patients with preoperative HN and supranormal renal function in DTPA renography

Primary Outcome Measures

Name	Time	Method
Hydronephrosis	postop 6 months	The grade of hydronephrosis would be check at 6 months postoperatively.

Secondary Outcome Measures

Name	Time	Method
renal parenchymal thickness	postop 6 months	Renal parenchymal thickness was measured.

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of