NCT01255917已完成不适用
Nerve Growth Factor in Chronic Pancreatitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- The levels of NGF in subjects with different morphological stages of chronic pancreatitis (CP) will be compared to the controls and in each morphological stage of CP will be correlated with pain scores.
研究概览
简要总结
This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis.
Hypothesis:
- Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem
- Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with established CP and none of the exclusion criteria mention below.
排除标准
- •Failure to obtain consent.
- •Any comorbid condition with expected survival < 1 year.
- •Patients with pacemaker, implanted metallic prosthesis or other contraindications to do MRCP.
- •Patients < 18 years of age at time of consent
结局指标
主要结局
The levels of NGF in subjects with different morphological stages of chronic pancreatitis (CP) will be compared to the controls and in each morphological stage of CP will be correlated with pain scores.
时间窗: 5 years
次要结局
- Correlate the expression of NGF and other inflammatory cytokines in the pancreatic juice in each morphological stage of CP.(5 years)
研究者
研究点 (1)
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