Comparison of Three Inspiratory-to-Expiratory Ratio During Mechanical Ventilation in Patients Undergoing Laparoscopic Surgeries: A Randomized Clinical Trial
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- To compare the effects of volume-controlled ventilation with I:E ratios of 1:1.5, 1:2, and 1:2.5 on respiratory mechanics in patients undergoing laparoscopic surgeries.
研究概览
简要总结
Summary This prospective, randomized clinical trial compares the effects of three different inspiratory-to-expiratory ratios , 1:1.5, 1:2, and 1:2.5 , during volume-controlled mechanical ventilation in adult patients undergoing laparoscopic surgeries.
A total of 75 patients , ASA I and II, aged 18 to 59 years, will be randomly assigned to one of the three groups. Standard anesthesia will be administered, and ventilation settings will be adjusted according to group allocation. Primary outcomes include respiratory mechanics such as peak airway pressure, plateau pressure, dynamic compliance, and airway resistance. Secondary outcomes include gas exchange parameters and hemodynamic stability during pneumoperitoneum.
The study aims to identify the optimal I:E ratio for improving lung mechanics and oxygenation while maintaining cardiovascular stability during laparoscopic upper abdominal surgeries. The findings are expected to guide anesthesiologists in selecting evidence-based ventilation strategies that may reduce postoperative pulmonary complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 59.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status I and II 2) Patients scheduled for elective laparoscopic surgeries 3) BMI 18.5 to 30 kg per metre square.
排除标准
- •Patient refusal 2) History of COPD, asthma, or restrictive lung disease 3) History of significant cardiovascular disease 4) Severe hepatic or renal impairment 5) Pregnancy 6) Emergency surgeries • BMI greater than 30 kg per metre square.
结局指标
主要结局
To compare the effects of volume-controlled ventilation with I:E ratios of 1:1.5, 1:2, and 1:2.5 on respiratory mechanics in patients undergoing laparoscopic surgeries.
时间窗: 0 min, 15 mins, 30 mins, 60 mins, after desufflation
次要结局
- To evaluate the impact of these three I:E ratios on gas exchange parameters and hemodynamic variables during pneumoperitoneum.(0 min, 15 mins, 30 mins, 60 mins, after desufflation)
研究者
Dr Prasanna Vadhanan
Vinayaka Missions Medical College and Hospital