Effects of Exercise Prediabetic Individuals

Not Applicable

Recruiting

• Conditions: Prediabetes / Type 2 Diabetes

• Registration Number: NCT06831266
• Lead Sponsor: Eastern Mediterranean University

Brief Summary

The aim of this study was to determine the effects of two different exercise protocols on body composition, aerobic capacity, blood lipid profile, some biomarkers, quality of life and exercise beliefs in participants at risk of diabetes.

Detailed Description

After being informed about the study and possible risks, all participants who gave written informed consent and met the eligibility requirements will be randomly assigned to 2 separate groups.

Study Timeline

• Study First Submitted: 2025-01-29
• Status Verified: 2025-02
• Study First Submitted QC: 2025-02-14
• Study First Posted: 2025-02-18
• Study Start: 2025-02-19
• Last Update Submitted: 2025-02-19
• Last Update Posted: 2025-02-21
• Primary Completion: 2025-06-30
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Being between 18-60 years old
• HbA1c value between 5.7%-6.4%
• BMI>24,9 kg/m²
• Being sedentary
• Not on any diet

Exclusion Criteria

• Insulin and derivative drug use
• Uncontrolled hypertension
• History of heart disease
• History of MI or stroke

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
HbAc	12 weeks	It is the amount of glycosylated hemoglobin in the blood.

Secondary Outcome Measures

Name	Time	Method
HDL	12 weeks	It is the amount of high-density lipoprotein in the blood.
LDL level LDL	12 weeks	It is the amount of low-density lipoprotein in the blood.
CRP	12 weeks	C-reactive protein is a protein produced in the liver.
Total cholesterol	12 weeks	Cholesterol is a lipid that is necessary for the construction of cell membranes in the body and the production of some hormones and vitamin D.
Triglyceride	12 weeks	It is a type of fat molecule found in the bloodstream and is used as the body's energy source.
Irisin	12 weeks	Irisin, defined as a myokine, is the proteolytic product of fibronectin type III domain 5 protein.
Adiponectin	12 weeks	Adiponectin is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown.
IL-6	12 weeks	Interleukin-6 is an endogenous chemical involved in inflammation and B cell maturation.
Resistin	12 weeks	Resistin is a hormone secreted from fat cells.
Kemerin	12 weeks	It is a protein that is involved in many metabolic events such as adipogenesis, angiogenesis and glucose homeostasis, including the chemoattractant function of the belt.
Leptin	12 weeks	Leptin is a hormone that acts on the hypothalamus through negative feedback secreted from fat cells, suppressing food intake and increasing energy expenditure.
Osteocalcin	12 weeks	Osteocalcin is a bone-specific protein found in osteoblasts.
TNF-alpha	12 weeks	Tumor necrosis factor alpha is a chemical messenger produced by the immune system that initiates inflammation.
Cardiometabolic risk level	12 weeks	Cardiometabolic risk has been defined as a cluster of metabolic and cardiovascular abnormalities, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and atherosclerosis, that predispose individuals to cardiovascular disease and type 2 diabetes.
Body composition	12 weeks	Body composition describes the amount of fat, bone, water and muscle in the body.
Aerobic capacity	12 weeks	Aerobic capacity is the capacity of large striated muscle groups to adapt to work using energy obtained from aerobic metabolism.
Exercise Health Belief Model Scale	12 weeks	Exercise Health Belief Model Scale is a 5-point Likert-type scale consists of 32 items.The scale consists of 5 factors and there is no reverse item. The highest and lowest score on the scale is 160 and 32, respectively. Higher scores indicate higher level of exercise health belief.
Short Form-36 Questionnaire	12 weeks	The Short Form (36) Health Survey is a 36-item, patient-reported survey of patient health. SF-36 measures eight scales: physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health.Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. High scores indicate good health status.

Trial Locations

Locations (2)

University of Kyrenia Hospital; 🇹🇷 Mersin, Kyrenia, Turkey

Eastern Mediterranean University; 🇹🇷 Mersin, Turkey