Observing the Perioperative Effects of Prehabilitation in Colorectal Cancer Patients

Completed

• Conditions: Colon Cancer
• Interventions: Other: Prehabilitation

• Registration Number: NCT04762914
• Lead Sponsor: Medway Primary Care Trust

Brief Summary

Quality Improvement Project to evaluate how prehabilitation can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Detailed Description

The aim was to evaluate how prehabilitation (PH) can be incorporated into our colorectal cancer pathway and assess its clinical benefits.

Patients underwent PH (exercise, nutrition and psychological support) before resection of colorectal carcinoma in a DGH over fourteen months. Patients were matched by operation, age, sex and ASA to non-prehabilitation (NPH) patients using a prospectively maintained database. Length of stay (LoS) and complication rate and 90-day readmission rates were compared using Wilcoxon and McNemar's methods.

Prehabilitation significantly improved peak VO2 and AT. This corresponds to a reduction in predicted 30-day mortality. Despite a higher Charlson index LoS was unchanged suggesting prehabilitation may permit safe resection in comorbid patients.

Study Timeline

• Study Start: 2018-09-01
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31
• Study First Submitted: 2021-01-22
• Status Verified: 2021-02
• Study First Submitted QC: 2021-02-17
• Last Update Submitted: 2021-02-17
• Study First Posted: 2021-02-21
• Last Update Posted: 2021-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• Adults over the age of 18 who had prehabilitation for colorectal cancer

Exclusion Criteria

• Children
• Patients who had prehabilitation but not for colorectal cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Prehabilitation (PH)	Prehabilitation	Patients who underwent prehabilitation prior to colorectal cancer resection

Primary Outcome Measures

Name	Time	Method
Length of stay	From date of operation to date of discharge in number of days over a 90 day follow up period	Time spent in hospital
Complication rate	Follow up over a period of 90 days following operation	All Clavien-Dindo complications

Secondary Outcome Measures

Name	Time	Method
Anaerobic threshold	CPET performed before prehabilitation and after prehabilitation (median of 36 days)	Measured by looking at CPET results pre- and post- prehab

Trial Locations

Locations (1)

Medway Hospitals NHS Trust; 🇬🇧 Gillingham, Kent, United Kingdom