NL-OMON54753已完成不适用
Angiotensin inhibitors during the perioperative period: to withdraw or to continue? - AIPOP (Angiotensin-inhibitors during the perioperative period)
niversitair Medisch Centrum Utrecht0 个研究点目标入组 334 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 334
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Chronic angiotensin-converting enzyme inhibitors and angiotensin receptor
- •blockers use for the treatment of hypertension. Patients who use a com-bination
- •pill with a diuretic are eligible as well;
- •- Scheduled for elective intermediate to high risk noncardiac surgery, defined
- •according to the European Society of Cardiology / European Society of
- •Anesthesiology guidelines on noncardiac surgery under general or regional
- •(spinal, epidural) anesthesia,
- •- Expected postoperative length of stay of at least one postoperative night
排除标准
- •- Severe chronic kidney disease, defined as eGFR<30 ml/min/1.73 m2 -
- •Angiotensin converting enzyme-inhibitors (ACEi)/Agiotensin receptor blockers
- •(ARB) use for the treatment of chronic systolic heart failure, defined as left
- •ventricular ejection fraction <=40%. Patients in whom the ejection fraction
- •currently has improved to >40% as a result of heart failure treatment (e.g.
- •ACEi/ARB use or chronic resynchronization therapy (CRT)) are also excluded -
- •ACEi/ARB use within one year after ST-elevated myocardial infarction, according
- •to the fourth universal definition of myocardial infarction (20,21) -
- •Transplant surgery - ACEi/ARB use in a combination pill together with a drug
- •other than a diuretic, including calcium channel blockers, beta-blockers and
- •neprilysin inhibitorsUse of drugs acting on the renin-angiotensin-aldosterone
- •system other than ACEi/ARB, e.g. aliskiren. - Patients who are not able to
- •manage their medication themselves, e.g. patients who use a medication box or
- •pill dispenser including the *Baxterrol*. - Urgent (<48 hours of diagnosis) or
- •emergency surgery - Nephrectomy (partial or complete, no matter the cause) -
- •Pheochromocytoma surgery - Carotid surgery, including endarterectomy and
- •carotid bypass surgery
研究者
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