Comparative Evaluation of Resveratrol Gel and Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in the Treatment of Periodontitis: Randomized Controlled Trial

Effective pharmacological treatment of infections is consistently constrained by microbial drug resistance, which calls for the development of new, powerful antimicrobial treatments. Chlorhexidine gel has been used extensively as a local drug delivery agent in periodontal treatment; nevertheless, its side effects, such as altered taste perception, tooth discoloration, and possible irritation of the mucosa, have led to the search for safer substitutes. Natural substances with the ability to circumvent microbial resistance pathways while reducing adverse effects, such as resveratrol, have become attractive options. A well researched plant phenol, resveratrol has strong anti-inflammatory, antioxidant, and antibacterial qualities that make it a useful treatment for a range of illnesses.  However, its low bioavailability and poor water solubility limit its therapeutic relevance. Despite these difficulties, the benefits of resveratrol, including its high membrane permeability and suitability for passive diffusion, make it particularly promising for localized drug delivery. In periodontitis, resveratrol shows potential to reduce inflammation, prevent oxidative stress, and promote tissue healing.  This study aims to explore resveratrol’s therapeutic applications, emphasizing its ability to be used as a new local drug delivery agent as an adjunct to scaling and root planing and compare it with the standard drug being used currently (chlorhexidine gel).