A study for evaluating the effect of low-protein brown rice on intestinal flora in patients with chronic kidney disease.

Not Applicable

• Conditions: Chronic kidney disease

• Registration Number: JPRN-UMIN000041832
• Lead Sponsor: Division of Endocrinology, Metabolism and Nephrology Department of Internal Medicine Keio University, School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-09-18
• Study Completion: 2022-04-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

1) Patients in whom it is difficult to obtain sufficient samples for analysis. 2) Patients who have cognitive or physical impairments that make it difficult to follow a diet. 3) Patients with inflammatory bowel disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
After obtaining the consent, participants will stop using probiotics such as yogurt for three months. After the initial assessment, participants consume a low-protein diet for 3 months and undergo a second assessment. After that, low-protein brown rice is consumed for 3 months and the final evaluation is performed. The intestinal flora is checked at each evaluation.

Secondary Outcome Measures

Name	Time	Method
Assessment of inflammation-related parameters at each time point. (IL -6, leptin, indoxyl sulfate, p-cresyl sulfate, microRNA, exosome)