Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome
Completed
- Conditions
- Infarction, BrainEmbolismAtrial Fibrillation
- Interventions
- Other: The presence and rate of MES measured by TCD monitoring
- Registration Number
- NCT06018090
- Lead Sponsor
- Centro Hospitalar De São João, E.P.E.
- Brief Summary
This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 61
Inclusion Criteria
- acute ischemic stroke admitted to the Stroke Unit, history of AF/flutter or a new diagnosis of AF at the stroke, and with a possibility to be monitored within 24 hours after symptom onset.
Exclusion Criteria
- use of anticoagulants at stroke onset; prosthetic valves; inadequate temporal bone window; uncooperative patients.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Acute Ischemic Stroke Patients with Atrial Fibrillation The presence and rate of MES measured by TCD monitoring -
- Primary Outcome Measures
Name Time Method Prevalence of MES Within 24 hours of symptom onset Poor functional outcome 90-days after stroke
- Secondary Outcome Measures
Name Time Method Ordinal Shift Analysis of mRS scale score 90-days after stroke
Trial Locations
- Locations (1)
Pedro Miguel Castro
🇵🇹Porto, Portugal