Comparison On Efficiency Of Surgical Pleth Index-Guided Traditional Epidural And Dural Puncture Epidural Analgesia Techniques In Percutaneous Nephrolithotomy: A Randomised Double Blind Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Analgesia
- Sponsor
- Ataturk University
- Enrollment
- 32
- Primary Endpoint
- consumption of local aneshesics
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
Primary aim of this study is to evaluate affect of SPI guided antinociception on total intraoperative consumption of local aneshesics during analgesia. Secondary aims are defining time interval between LA administration and SPI value dropping under 50 and hemodynamy. Tertiary results are total mean local anesthesic consumption per hour, mean LA bolus number, total norepinephrine, ephedrine and atrophine consumption, mean intraoperative heart rate, mean arterial pressure, BIS and minimal alveolar concentration, percentage of intraoperative surgery time during which SPI>50, time passed until first post operative analgesia need, time needed to be discharged from PACU after operation (evaluated via Aldrte score) and post operative side effects (nausea, vomiting, sedatition and piruritis)
Investigators
Aysenur Dostbil
Clinical Professor
Ataturk University
Eligibility Criteria
Inclusion Criteria
- •aged 18-60
- •ASA I-III
- •grade I unilateral PNL
Exclusion Criteria
- •BMI \> 40 kg/m2
- •drug or alcohol abuse history in the last 6 mounts
- •chronic opoid usage or had chronic pain longer than 6 weeks
- •peripheral and central neurological disorders
- •preoperative hemodynamic disorders
- •irregular sinus rhythm and pace makers
- •diabetes, severe lung and major liver diseases with increasing biluribin
- •use of anti-muscarinics, α2-adrenergic agonists, β1-adrenergic agonists, anti arrhythmic; who used chronic psychoactive drugs in last 90 days
- •who are pregnant and breast feeding
- •not willing to participate
Outcomes
Primary Outcomes
consumption of local aneshesics
Time Frame: intraoperative
to evaluate affect of SPI guided antinociception on total intraoperative consumption of local aneshesics during analgesia
Secondary Outcomes
- time interval and SPI value dropping(intraoperative)
- local anesthesic consumption(during the procedure/surgery and during 30 minutes of PACU stay)