Role of Hydroxychloroquine to Improve Endothelial Dysfunction in Patients With Rheumatoid Arthritis
Not Applicable
Completed
- Conditions
- Rheumatoid Arthritis
- Interventions
- Drug: Placebo
- Registration Number
- NCT03085940
- Lead Sponsor
- Indonesia University
- Brief Summary
Rheumatoid arthritis (RA) increase cardiovascular risk and endothelial dysfunction. Hydroxychloroquine (HCQ) is expected to improve endothelial dysfunction through some metabolic effects. The investigators intend to find the role of HCQ to improve endothelial dysfunction in RA patients. This study will also evaluate correlation HOMA-IR (homeostasis model assessment-estimated insulin resistance), FFA (free fatty acid) and ox-LDL (oxidized-LDL) level change, with endothelial dysfunction improvement.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 37
Inclusion Criteria
- Rheumatoid Arthritis patients (2010 ACR/EULAR criteria)
- Being or will be treated with methotrexate (monotherapy)
- Agree to join the study
Exclusion Criteria
- Autoimmune diseases other than RA
- Acute severe infection, acute coronary syndrome, heart failure, stroke
- Malignancy or chronic inflammatory diseases
- Eye disease involving the retina and visual field defects
- G6PD (glucose 6-phosphate dehydrogenase) deficiency
- History of smoking within last 5 years
- Lipid lowering, insulin resistance lowering, antidiabetic, insulin, ACE(angiotensin converting enzyme)-inhibitor or ARB(angiotensin receptor blocker) drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - Hydroxychloroquine Hydroxychloroquine -
- Primary Outcome Measures
Name Time Method Endothelial dysfunction marker 3 months E-Selektine
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ciptomangunkusumo Hospital
🇮🇩Jakarta, Indonesia