Cognitive Function of Alcoholic Liver Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- BMI
研究概览
简要总结
Differences in cognitive function between patients with viral and alcoholic compensated liver cirrhosis
详细描述
Hepatic encephalopathy (HE) is one of the important complications of liver cirrhosis (LC). HE exhibits alterations in cognitive, psychomotor-intellectual, emotional, behavioral, or fine-motor functions. Approximately 22-74 % of patients with non-fulminant HE have MHE with a frequency proportional to the patient age and the severity of the liver disease. Patients with MHE exhibit disability in most functional behaviors such as social connection, alertness, emotional behavior, sleep, work, and leisure.
Alcohol consumption itself has a toxic effect on the brain. It has been documented that there is a neuronal loss in the cerebral cortex, hypothalamus, hippocampus, septal region, and cerebellum of an alcoholic brain.
The major causes of LC are hepatitis B/C viral infection and chronic alcohol consumption. The most widely accepted theory of HE pathogenesis is that toxic substances derived from the gut affect cerebral function after liver dysfunction or portosystemic shunting. This proposed pathogenetic mechanism could apply to viral compensated LC. However, it is difficult to explain the development of MHE in patients with alcoholic LC in this manner.
Therefore, patients with alcoholic LC may have different cognitive dysfunction as compared to patients with viral LC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 22 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Those who agreed to participate in this study and signed a written consent
- •Those who have no evidence of neurological impairment
排除标准
- •Those who have decompensated liver cirrhosis
- •Those who have a high MELD score (≥20)
- •Those who have OHE during admission
- •Those who have parients' refusal
结局指标
主要结局
BMI
时间窗: 10 years
Compare the body mass index
Liver function
时间窗: 10 years
Compare the liver enzyme level Serum biochemical parameters included total bilirubin(mg/dL), alanine aminotransferase(ALT(IU/L)), haptoglobin(mg/dL), aspartate aminotransferase (AST (IU/L)), gamma glutamyltranspeptidase (GGT(IU/L)), alkaline phosphatase (ALP(IU/L)), albumin(g/dL), blood urea nitrogen(mg/dL), creatinine(mg/dL), α-fetoprotein (AFP(ng/mL)), prothrombin time, blood glucose(mg/dL), triglycerides(mg/dL), and total cholesterol(mg/dL).
Cognitive function (Neuropsychological test)
时间窗: 10 years
Assessment to measure cognitive function using neuropsychological test
次要结局
未报告次要终点
研究者
Ki Tae Suk
Proffesor
Chuncheon Sacred Heart Hospital