Alcohol Research Consortium in HIV-Intervention Research Arm
Overview
- Phase
- Phase 4
- Intervention
- Computerized Brief Intervention (CBI)
- Conditions
- HIV Positive
- Sponsor
- University of Alabama at Birmingham
- Enrollment
- 4985
- Locations
- 2
- Primary Endpoint
- Audit-C Score on a Scale
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Aim 1: Examine effects of algorithm-guided alcohol treatment on alcohol consumption and alcohol use Disorders (AUD) symptoms.
Aim 2: Examine effects of algorithm-guided alcohol treatment on retention in HIV care and HIV-related outcomes.
Aim 3: Examine effects of algorithm-guided alcohol treatment on comorbid conditions
Detailed Description
Aim 1: Examine effects of algorithm-guided alcohol treatment on alcohol consumption and alcohol use Disorders (AUD) symptoms. Hypothesis 1A: Patients who are treated using algorithm-guided alcohol treatment will decrease drinking quantity and or frequency compared to pre-algorithm levels. Hypothesis 1B. Patients who are treated using algorithm-guided treatment will decrease current AUD symptoms compared to pre-algorithm symptoms levels. Aim 2: Examine effects of algorithm-guided alcohol treatment on retention in HIV care and HIV-related outcomes. Hypothesis 2A. Patients treated using algorithm-guided treatment will increase adherence to clinic visits and HIV medications compared to pre-algorithm levels. Hypothesis 2B. Patients who receive algorithm-guided treatment will have improved HIV biomarkers (e.g., CD4 and VL). Hypothesis 3B. There will be a positive relationship between VL and alcohol consumption measured by self-report and PEth level. Aim 3: Examine effects of algorithm-guided alcohol treatment on comorbid conditions (e.g., depression, anxiety, HCV, other drug use disorders). Hypothesis 3A: Persons living with HIV (PLWH) with co-morbid depression and anxiety receiving algorithm-guided treatment will have better alcohol, mental health and HIV treatment outcomes compared to similar individuals in SC. Hypothesis 3B: PLWH with comorbid HCV receiving algorithm-guided treatment will have improved FIB4 results and reduced likelihood of HCV recurrence compared to persons in SC. Hypothesis 3C: Other drug use will decrease among those receiving algorithm-guided treatment vs SC.
Investigators
Karen Cropsey
Principal Investigator
University of Alabama at Birmingham
Eligibility Criteria
Inclusion Criteria
- •At least 18 years or older;
- •Receiving HIV care at the UAB, UW or UCSD clinics and not anticipating changing clinics over the next 12 months;
- •AUDIT-C score \> 3 women or \> 4 men at time of PRO.
Exclusion Criteria
- •Non-English speaking;
- •Acutely suicidal, manic, acutely intoxicated, or otherwise not stable enough to provide informed consent.
Arms & Interventions
No dx of alcohol use disorder, panic or depression
Computerized Brief Intervention (CBI)- a video about alcohol abuse
Intervention: Computerized Brief Intervention (CBI)
Risky drinking, no dx of AUD, has panic or depression
Computerized Brief Intervention (CBI)- a video about alcohol abuse, plus 4 sessions of counseling called Motivational Enhancement Therapy
Intervention: Computerized Brief Intervention (CBI)
Risky drinking, no dx of AUD, has panic or depression
Computerized Brief Intervention (CBI)- a video about alcohol abuse, plus 4 sessions of counseling called Motivational Enhancement Therapy
Intervention: CBT4CBT
Dx of AUD with or without panic or depression
Computerized Brief Intervention (CBI)- a video about alcohol abuse, plus 4 sessions of counseling called Motivational Enhancement Therapy plus a recommendation for Alcohol Pharmacotherapy (APT). The drugs recommended in the APT are all standard of care drugs for alcohol treatment and are not under study in this protocol.
Intervention: Computerized Brief Intervention (CBI)
Dx of AUD with or without panic or depression
Computerized Brief Intervention (CBI)- a video about alcohol abuse, plus 4 sessions of counseling called Motivational Enhancement Therapy plus a recommendation for Alcohol Pharmacotherapy (APT). The drugs recommended in the APT are all standard of care drugs for alcohol treatment and are not under study in this protocol.
Intervention: CBT4CBT
Dx of AUD with or without panic or depression
Computerized Brief Intervention (CBI)- a video about alcohol abuse, plus 4 sessions of counseling called Motivational Enhancement Therapy plus a recommendation for Alcohol Pharmacotherapy (APT). The drugs recommended in the APT are all standard of care drugs for alcohol treatment and are not under study in this protocol.
Intervention: Recommendation and Counseling for Alcohol Pharmacotherapy
Outcomes
Primary Outcomes
Audit-C Score on a Scale
Time Frame: 18 month window
Difference in Audit-C score, pre and post intervention. The AUDIT-C is scored on a scale of 0-12 (scores of 0 reflect no alcohol use). In men, a score of 4 or more is considered positive; in women, a score of 3 or more is considered positive. Generally, the higher the AUDIT-C score, the more likely it is that the patient's drinking is affecting his/her health and safety.
Secondary Outcomes
- PEth Levels(Between baseline and 6 month follow-up)